Results 31 to 40 of about 365,375 (316)
Comparison of Deep Learning and Deterministic Algorithms for Control Modeling
Sensors, 2022 Controlling nonlinear dynamics arises in various engineering fields. We present efforts to model the forced van der Pol system control using physics-informed neural networks (PINN) compared to benchmark methods, including idealized nonlinear feedforward (
Hanfeng Zhai, Timothy Sands
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
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Hoist-Based Shape Memory Alloy Actuator with Multiple Wires for High-Displacement Applications
Actuators, 2023 Shape memory alloys (SMAs) are smart materials that change their crystalline structures when subjected to heat or tension, resulting in a macroscopic deformation.
Carmen Ballester +4 more
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Results in Physics, 2019 For multifunctional optimization design of honeycomb structures, the high stiffness hierarchical honeycombs with stochastic Voronoi substructures (HHSVS) are proposed by substituting cell walls of the regular hexagonal honeycombs (ORHH) with Voronoi ...
Bin Wang +6 more
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FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
Energies, 2019 A novel bistable electromagnetic vibration energy harvester (BEMH) is constructed and optimized in this study, based on a nonlinear system consisting mainly of a flexible membrane and a magnetic spring.
Bei Zhang +6 more
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, 2017 Nonlinear behavior is the general rule in physics and nature. Linear models, obtained by linearization or identification, are in general crude approximations of nonlinear behaviors of plants in the neighbourhood of an operating point. However, in many cases such as startup, shutdown, or important transient regimes, study of batch and fed-batch ...
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ACS Omega, 2022 This paper presents the novelty on a nonlinear proportional integral derivative (NPID) controller developed from the gain values obtained using the Lyapunov-based nonlinear model predictive controller (LyNMPC). The tuning parameters of the proposed controller are taken from the dynamics of the nonlinear system, and these parmeters are dynamic with ...
Suraj Suresh Kumar +4 more
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FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source