Results 131 to 140 of about 26,484 (294)

Genipin‐Crosslinked, Silane‐Anchored 3D Tumor–Stroma Microtissues for High‐Content On‐Chip Drug Testing

open access: yesAdvanced Healthcare Materials, EarlyView.
We describe a microfluidic tumor‐stroma co‐culture model, engineered to resist collagen‐hydrogel contraction driven by fibroblast activity. Surface silanization with APTES covalently anchors the matrix to the chip, while Genipin crosslinking progressively increases stiffness and elasticity without harming cells. This supports >10 days of co‐culture and
Doriane Le Manach   +4 more
wiley   +1 more source

Functional Precision Oncology Approach Using Nanoliter Droplet Array for Drug Sensitivity Testing in Lung Cancer

open access: yesAdvanced Healthcare Materials, EarlyView.
A miniaturized drug sensitivity and resistance testing (DSRT) workflow based on the Droplet Microarray (DMA) platform enables functional drug testing using minimal patient‐derived tumor material. By screening nanoliter‐scale droplets containing as few as 300 cells, this approach generates reproducible and tumor‐specific drug response profiles ...
Maryam Salarian   +7 more
wiley   +1 more source

Video Analysis Via Nonlinear Dimensionality Reduction [PDF]

open access: yes, 2007
In this work we present an application of nonlinear dimensionality reduction techniques for video analysis. We review several methods for dimensionality reduction and then concentrate on the study of Diffusion Maps. First we show how diffusion maps can be applied to video analysis.
openaire   +1 more source

Efficient Parallel Algorithm for Nonlinear Dimensionality Reduction on GPU

open access: yes, 2012
[[abstract]]Advances in nonlinear dimensionality reduction provide a way to understand and visualize the underlying structure of complex data sets. The performance of large-scale nonlinear dimensionality reduction is of key importance in data mining ...
Tsung Tai Yeh;Tseng-Yi Chen;Wei-Kuan Shih;Yeh-Chiu Chen
core  

Riemannian manifold learning for nonlinear dimensionality reduction

open access: yes, 2006
In recent years, nonlinear dimensionality reduction (NLDR) techniques have attracted much attention in visual perception and many other areas of science. We propose an efficient algorithm called Riemannian manifold learning (RML).
Hongbin Zha   +8 more
core   +1 more source

Packed Hydrogel Microfibers as Scaffolds Supporting Dynamic Cellular Behavior and Biomaterial Inks in 3D Printing

open access: yesAdvanced Healthcare Materials, EarlyView.
Packed hydrogel microfiber (PHM) materials consist of flexible and high aspect ratio hydrogel components that, as a bulk material, are simultaneously mechanically robust and dynamic. Cells cultured in or on PHM scaffolds can be influenced by topographical cues or interact with a dynamic environment that permits cell spreading and multicellular ...
M. Gregory Grewal   +7 more
wiley   +1 more source

Microengineered Gradient Hydrogels for Mechanobiology

open access: yesAdvanced Healthcare Materials, EarlyView.
Gradient hydrogels are used to mimic the mechanical heterogeneity in native tissues, offering powerful in vitro platforms to study cell‐material interactions in diverse pathophysiological contexts. Here, we present a comprehensive review of the design and experimental considerations for stiffness gradient hydrogels, discussing exemplary achievements ...
Shin Wei Chong   +4 more
wiley   +1 more source

Learning Propagators for Sea Surface Height Forecasts Using Koopman Autoencoders

open access: yesGeophysical Research Letters
Due to the wide range of processes impacting the sea surface height (SSH) on daily‐to‐interannual timescales, SSH forecasts are hampered by numerous sources of uncertainty.
Andrew E. Brettin   +2 more
doaj   +1 more source

Nonlinear dimensionality reduction methods in climate data analysis

open access: yes, 2008
Linear dimensionality reduction techniques, notably principal component analysis, are widely used in climate data analysis as a means to aid in the interpretation of datasets of high dimensionality.
Ross, Ian
core  

Gaussian processes autoencoder for dimensionality reduction

open access: yes, 2014
Learning low dimensional manifold from highly nonlinear data of high dimensionality has become increasingly important for discovering intrinsic representation that can be utilized for data visualization and preprocessing.
Cai, Z.   +7 more
core   +1 more source

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