Results 41 to 50 of about 26,484 (294)
eLife, 2021 Cortical circuits are thought to contain a large number of cell types that coordinate to produce behavior. Current in vivo methods rely on clustering of specified features of extracellular waveforms to identify putative cell types, but these capture only
Eric Kenji Lee +6 more
doaj +1 more source
Parallel nonlinear dimensionality reduction using GPU acceleration
, 2021 Dimensionality reduction is usually an essential step in data mining and classical machine learning from high-dimensional data. Uniform Manifold Approximations Projections (UMAP) is a recently developed nonlinear dimensionality reduction method that is ...
Qu, Zhonglin (S33642) +3 more
core +1 more source
Visual Prediction of Rover Slip: Learning Algorithms and Field Experiments [PDF]
, 2008 Perception of the surrounding environment is an essential tool for intelligent navigation in any autonomous vehicle. In the context of Mars exploration, there is a strong motivation to enhance the perception of the rovers beyond geometry-based obstacle ...
Angelova, Anelia Nedelcheva
core +1 more source
Foundations of Coupled Nonlinear Dimensionality Reduction
CoRR, 2015 In this paper we introduce and analyze the learning scenario of \emph{coupled nonlinear dimensionality reduction}, which combines two major steps of machine learning pipeline: projection onto a manifold and subsequent supervised learning. First, we present new generalization bounds for this scenario and, second, we introduce an algorithm that follows ...
Dmitry Storcheus +2 more
openaire +2 more sources
Local Feature Discriminant Projection
, 2016 In this paper, we propose a novel subspace learning algorithm called Local Feature Discriminant Projection (LFDP) for supervised dimensionality reduction of local features.
Zhen, Xiantong +3 more
core +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
The Intrinsic Dimensionality of Attractiveness: A Study in Face Profiles [PDF]
, 2012 The study of human attractiveness with pattern analysis techniques is an emerging research field. One still largely unresolved problem is which are the facial features relevant to attractiveness, how they combine together, and the number of independent ...
Andrea Bottino +3 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source