Results 51 to 60 of about 115,342 (279)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Parallel t-SNE Applied to Data Visualization in Smart Cities

IEEE Access, 2020
The growth of smart city applications is increasingly around the world, many cities invest in the development of these systems intending to improve the management and life of their residents.
Maximiliano Araujo Da Silva Lopes, Adriao D. Doria Neto, Allan De Medeiros Martins   +2 more
doaj   +1 more source

The Shape and Dimensionality of Phylogenetic Tree-Space Based on Mitochondrial Genomes [PDF]

, 2010
Phylogenetic analyses of large and diverse data sets generally result in large sets of competing phylogenetic trees. Consensus tree methods used to summarize sets of competing trees discard important information regarding the similarity and distribution ...
James C. Wilgenbusch, Kyle A. Gallivan, Wen Huang   +2 more
core   +1 more source

Quantum Discriminant Analysis for Dimensionality Reduction and Classification

, 2016
We present quantum algorithms to efficiently perform discriminant analysis for dimensionality reduction and classification over an exponentially large input data set.
Cong, Iris, Duan, Luming
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Visualization of large-scale user association feature data based on a nonlinear dimensionality reduction method

Nonlinear Engineering
The prosperity of data science and the booming growth of the internet industry have made the analysis and processing of large-scale user-related feature data a particularly important issue in modern society.
Nong Linlin
doaj   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

A Clustering-Based Dimensionality Reduction Method Guided by POD Structures and Its Application to Convective Flow Problems

Algorithms
Proper orthogonal decomposition (POD) is a widely used linear dimensionality reduction technique, but it often fails to capture critical features in complex nonlinear flows.
Qingyang Yuan, Bo Zhang
doaj   +1 more source

ENSO dynamics in current climate models: an investigation using nonlinear dimensionality reduction [PDF]

Nonlinear Processes in Geophysics, 2008
Linear dimensionality reduction techniques, notably principal component analysis, are widely used in climate data analysis as a means to aid in the interpretation of datasets of high dimensionality.
I. Ross, P. J. Valdes, S. Wiggins
doaj