Results 41 to 50 of about 150,012 (267)
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Three-Point Boundary Value Problems for the Langevin Equation with the Hilfer Fractional Derivative
Advances in Mathematical Physics, 2020 We discuss the existence and uniqueness of solutions for the Langevin fractional differential equation and its inclusion counterpart involving the Hilfer fractional derivatives, supplemented with three-point boundary conditions by means of standard tools
Athasit Wongcharoen +3 more
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Advances in Mechanical Engineering, 2017 This article studies an output feedback attitude tracking control problem for rigid spacecraft in the presence of parameter uncertainties and external disturbances. First, an anti-unwinding attitude control law is designed using the integral sliding mode
Anuchit Jitpattanakul +1 more
doaj +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher +10 more
wiley +1 more source
Nonlinear dynamic process monitoring using deep dynamic principal component analysis
Systems Science & Control Engineering, 2022 Data-driven method has gained its popularity in fault detection. Conventional methods are associated with one-single-layer process monitoring. Information extracted by such a method may not be sufficient to detect some faults for complicated process ...
Simin Li +3 more
doaj +1 more source
A Q‐Learning Algorithm to Solve the Two‐Player Zero‐Sum Game Problem for Nonlinear Systems
International Journal of Adaptive Control and Signal Processing, Volume 39, Issue 3, Page 566-581, March 2025.A Q‐learning algorithm to solve the two‐player zero‐sum game problem for nonlinear systems. ABSTRACT This paper deals with the two‐player zero‐sum game problem, which is a bounded L2$$ {L}_2 $$‐gain robust control problem. Finding an analytical solution to the complex Hamilton‐Jacobi‐Issacs (HJI) equation is a challenging task.
Afreen Islam +2 more
wiley +1 more source
A Hybrid Proximal Algorithm for the Sum of Monotone Operators with Multivalued Mappings
Journal of Function Spaces, 2018 We modify a hybrid method and a proximal point algorithm to iteratively find a zero point of the sum of two monotone operators and fixed point of nonspreading multivalued mappings in a Hilbert space by using the technique of forward-backward splitting ...
N. Kaewyong +3 more
doaj +1 more source
International Journal of Adaptive Control and Signal Processing, EarlyView.This article proposes a convergent adaptive observer for a damped wave PDE and an infinite‐dimensional ODE coupled in cascade using sampled‐in‐space ODE state measurements. The proposed observer estimates the distributed states of the PDE and ODE along with unknown PDE parameters and spatial input.
Zehor Belkhatir +2 more
wiley +1 more source