Results 51 to 60 of about 806,938 (302)
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Performance-limit criteria for the design of fast-response servo-actuation systems [PDF]
, 1970 Analysis of a typical nonlinear electrohydraulic servo-model establishes the dynamic-performance capabilities of servo-actuation ...
Zeller, J. R.
core +1 more source
Energy harvesting from the nonlinear oscillations of magnetic levitation [PDF]
, 2009 This paper investigates the design and analysis of a novel energy harvesting device that uses magnetic levitation to produce an oscillator with a tunable resonance. The governing equations for the mechanical and electrical domains are derived to show the
Arnold +17 more
core +2 more sources
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Three-Point Boundary Value Problems for the Langevin Equation with the Hilfer Fractional Derivative
Advances in Mathematical Physics, 2020 We discuss the existence and uniqueness of solutions for the Langevin fractional differential equation and its inclusion counterpart involving the Hilfer fractional derivatives, supplemented with three-point boundary conditions by means of standard tools
Athasit Wongcharoen +3 more
doaj +1 more source
High-impact dynamic-response analysis of nonlinear structures [PDF]
, 1971 Program predicts expected deformations and stresses in nonlinear simple geometric structures subjected to high-impact loading. Technique is based on node-wise predictor-corrector approach and requires moderate computer storage and run time for most ...
Gupta, K. K.
core +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Advances in Mechanical Engineering, 2017 This article studies an output feedback attitude tracking control problem for rigid spacecraft in the presence of parameter uncertainties and external disturbances. First, an anti-unwinding attitude control law is designed using the integral sliding mode
Anuchit Jitpattanakul +1 more
doaj +1 more source
Nonlinear Analysis of the Dynamics of DNA Breathing [PDF]
Journal of Biological Physics, 2009 The base pairs that encode the genetic information in DNA show large amplitude localized excitations called DNA breathing. We discuss the experimental observations of this phenomenon and its theoretical analysis. Starting from a model introduced to study the thermal denaturation of DNA, we show that it can qualitatively describe DNA breathing but is ...
Peyrard, Michel +2 more
openaire +3 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu +10 more
wiley +1 more source