Results 51 to 60 of about 803,646 (330)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Nonlinear static and dynamic analysis of mixed cable elements [PDF]

, 2017
This paper presents a family of finite elements for the nonlinear static and dynamic analysis of cables based on a mixed variational formulation in curvilinear coordinates and finite deformations.
Crusells Girona, Miquel, Filippou, Filip C., Taylor, Robert L.   +2 more
core   +1 more source

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez, Corinne Pettigrew, Yuxin Zhu, Claire Anderson, Guray Erus, Christos Davatzikos, Michael Miller, Abhay Moghekar, Sungtaek Oh, Chan‐Hyun Na, Marilyn Albert, Paul Worley, Anja Soldan   +12 more
wiley   +1 more source

High-impact dynamic-response analysis of nonlinear structures [PDF]

, 1971
Program predicts expected deformations and stresses in nonlinear simple geometric structures subjected to high-impact loading. Technique is based on node-wise predictor-corrector approach and requires moderate computer storage and run time for most ...
Gupta, K. K.
core   +1 more source

Diffusion Tractography Biomarker for Epilepsy Severity in Children With Drug‐Resistant Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To develop a novel deep‐learning model of clinical DWI tractography that can accurately predict the general assessment of epilepsy severity (GASE) in pediatric drug‐resistant epilepsy (DRE) and test if it can screen diverse neurocognitive impairments identified through neuropsychological assessments.
Jeong‐Won Jeong, Min‐Hee Lee, Hiroshi Uda, Yoon Ho Hwang, Michael Behen, Aimee Luat, Csaba Juhász, Eishi Asano   +7 more
wiley   +1 more source

Pricing options in illiquid markets: optimal systems, symmetry reductions and exact solutions

, 2010
We study a class of nonlinear pricing models which involves the feedback effect from the dynamic hedging strategies on the price of asset introduced by Sircar and Papanicolaou. We are first to study the case of a nonlinear demand function involved in the
Bordag, Ljudmila A.
core   +1 more source

Adaptive output feedback integral sliding mode attitude tracking control of spacecraft without unwinding

Advances in Mechanical Engineering, 2017
This article studies an output feedback attitude tracking control problem for rigid spacecraft in the presence of parameter uncertainties and external disturbances. First, an anti-unwinding attitude control law is designed using the integral sliding mode
Anuchit Jitpattanakul, Chutiphon Pukdeboon   +1 more
doaj   +1 more source

Nonlinear Analysis of the Dynamics of DNA Breathing [PDF]

Journal of Biological Physics, 2009
The base pairs that encode the genetic information in DNA show large amplitude localized excitations called DNA breathing. We discuss the experimental observations of this phenomenon and its theoretical analysis. Starting from a model introduced to study the thermal denaturation of DNA, we show that it can qualitatively describe DNA breathing but is ...
Peyrard, Michel, Cuesta-Lopez, Santiago, James, Guillaume   +2 more
openaire   +3 more sources

The Relationship Between Inflammation and Central Nervous System in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aim Multiple sclerosis is an autoimmune demyelination disease that is seen especially in the young population and has a progressive course, causing motor, sensory, and cognitive deficits. In the literature, the pathogenesis of MS disease and the interconnection between the immune and central nervous system in the disease have not been fully ...
Gamze Ansen, Ali Behram Salar, Abdulkadir Ermis, Erkingul Birday, Lutfu Hanoglu, Bayram Ufuk Sakul   +5 more
wiley   +1 more source

Three-Point Boundary Value Problems for the Langevin Equation with the Hilfer Fractional Derivative

Advances in Mathematical Physics, 2020
We discuss the existence and uniqueness of solutions for the Langevin fractional differential equation and its inclusion counterpart involving the Hilfer fractional derivatives, supplemented with three-point boundary conditions by means of standard tools
Athasit Wongcharoen, Bashir Ahmad, Sotiris K. Ntouyas, Jessada Tariboon   +3 more
doaj   +1 more source