Results 51 to 60 of about 239,562 (315)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

On discrete analogues of nonlinear implicit differential equations

open access: yesAdvances in Difference Equations, 2006
This paper deals with some classes of nonlinear implicit difference equations obtained via discretization of nonlinear differential-algebraic or partial differential-algebraic equations.
Anh Pham Ky, Loi Le Cong
doaj   +2 more sources

On the covering dimension of the set of solutions of some nonlinear equations [PDF]

open access: yes, 1986
We prove an abstract theorem whose sole hypothesis is that the degree of a certain map is nonzero and whose parametric equations are studied using cohomological mconclusions imply sharp, multidimensional continuation results.
Pejsachowicz, Jacobo   +4 more
core  

Lagrangian Averaging, Nonlinear Waves, and Shock Regularization [PDF]

open access: yes, 2005
In this thesis, we explore various models for the flow of a compressible fluid as well as model equations for shock formation, one of the main features of compressible fluid flows.
Bhat, Harish Subrahmanya
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Practical Ulam-Hyers-Rassias stability for nonlinear equations [PDF]

open access: yesMathematica Bohemica, 2017
In this paper, we offer a new stability concept, practical Ulam-Hyers-Rassias stability, for nonlinear equations in Banach spaces, which consists in a restriction of Ulam-Hyers-Rassias stability to bounded subsets.
Jin Rong Wang, Michal Fečkan
doaj   +1 more source

Analysis of complex nonlinear reaction-diffusion equations [PDF]

open access: yes, 2008
A mathematical analysis has been carried out for some nonlinear reaction- diffusion equations on open bounded convex domains Ω C R(^d)(d < 3) with Robin boundary conditions- Existence, uniqueness and continuous dependence on initial data of weak and ...
Al-Ofl, Abdalaziz Saleem
core  

New extended generalized Kudryashov method for solving three nonlinear partial differential equations

open access: yes, 2020
New extended generalized Kudryashov method is proposed in this paper for the first time. Many solitons and other solutions of three nonlinear partial differential equations (PDEs), namely, the (1+1)-dimensional improved perturbed nonlinear Schrödinger ...
Alngar, Mohamed E.M.   +2 more
core   +1 more source

Conservative numerical methods for model kinetic equations [PDF]

open access: yes, 2007
A new conservative discrete ordinate method for nonlinear model kinetic equations is proposed. The conservation property with respect to the collision integral is achieved by satisfying at the discrete level approximation conditions used in deriving the ...
Titarev, Vladimir A.
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

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