Results 71 to 80 of about 310,302 (319)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Improved basal drag of the West Antarctic Ice Sheet from L-curve analysis of inverse models utilizing subglacial hydrology simulations [PDF]

The Cryosphere
The West Antarctic Ice Sheet (WAIS) is the focus of current research due to its susceptibility to collapse, which could potentially contribute to rising sea levels.
L.-S. Höyns, L.-S. Höyns, L.-S. Höyns, T. Kleiner, A. Rademacher, M. Rückamp, M. Wolovick, M. Wolovick, A. Humbert, A. Humbert   +9 more
doaj   +1 more source

Are Central Banks following a linear or nonlinear (augmented) Taylor rule? [PDF]

, 2008
The Taylor rule establishes a simple linear relation between the interest rate, inflation and output gap. However, this relation may not be so simple. To get a deeper understanding of central banks’ behaviour, this paper asks whether central banks are ...
Castro, Vítor Manuel Alves
core   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Existence and convergence theorems for evolutionary hemivariational inequalities of second order

Electronic Journal of Differential Equations, 2015
This article concerns with a class of evolutionary hemivariational inequalities in the framework of evolution triple. Based on the Rothe method, monotonicity-compactness technique and the properties of Clarke's generalized derivative and gradient, the
Zijia Peng, Cuie Xiao
doaj  

Visco-potential free-surface flows and long wave modelling [PDF]

, 2008
In a recent study [DutykhDias2007] we presented a novel visco-potential free surface flows formulation. The governing equations contain local and nonlocal dissipative terms.
Bona, Bona, Bona, Boussinesq, Byatt-Smith, Chen, Chester, Denys Dutykh, Dias, Dias, Dutykh, Dutykh, Dyachenko, Dyachenko, Grimshaw, Joseph, Kakutani, Keulegan, Khabakhpashev, Khabakhpashev, Lamb, Lighthill, Liu, Liu, Liu, Liu, Longuet-Higgins, Matsuuchi, Mei, Mei, Miles, Sugimoto, Sugimoto, Torsvik, Wu, Zabusky, Zakharov, Zakharov   +37 more
core   +4 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Non-degenerate implicit evolution inclusions

Electronic Journal of Differential Equations, 2000
We prove the existence of solutions for the implicit evolution inclusion $$ ( B(t) u( t) ) ' + A(t,u(t)) i f(t) $$ under conditions that are easy to verify on the set valued operator $A( t,cdot)$ and that do not imply the operator is monotone.
Kenneth Kuttler
doaj  

Fiber-reinforced concrete for complex engineering conditions: material properties, nonlinear response and sustainable applications in spaceflight

High Temperature Materials and Processes
As space missions evolve toward longer durations and deeper missions, structural materials face unprecedented challenges in extreme extraterrestrial environments, such as extreme temperature swings, intense radiation, cyclic loading, and crack ...
Liu Junyu, Liu Xi
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source