Results 51 to 60 of about 16,692 (242)
On the set of solutions of a class of nonlinear evolution inclusions [PDF]
Kodai Mathematical Journal, 1992 The present paper deals with properties of the solution set of the Cauchy problem for nonlinear evolution inclusions of the form \(x'(t)\in A(t,x(t))+f(t)\), a.e., and \(x'(t)\in A(t,x(t))+F(t,x(t))\), a.e., where \(A\) and \(F\) are multivalued mappings.
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
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Non-degenerate implicit evolution inclusions
Electronic Journal of Differential Equations, 2000 We prove the existence of solutions for the implicit evolution inclusion $$ ( B(t) u( t) ) ' + A(t,u(t)) i f(t) $$ under conditions that are easy to verify on the set valued operator $A( t,cdot)$ and that do not imply the operator is monotone.
Kenneth Kuttler
doaj
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
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High Temperature Materials and ProcessesAs space missions evolve toward longer durations and deeper missions, structural materials face unprecedented challenges in extreme extraterrestrial environments, such as extreme temperature swings, intense radiation, cyclic loading, and crack ...
Liu Junyu, Liu Xi
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Improved basal drag of the West Antarctic Ice Sheet from L-curve analysis of inverse models utilizing subglacial hydrology simulations [PDF]
The CryosphereThe West Antarctic Ice Sheet (WAIS) is the focus of current research due to its susceptibility to collapse, which could potentially contribute to rising sea levels.
L.-S. Höyns +9 more
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Topological properties of the solution set of a class of nonlinear evolutions inclusions [PDF]
Czechoslovak Mathematical Journal, 1997 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
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FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
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Self-consistent Nonlinear Classical Cepheid Pulsations during Stellar Evolution with MESA
The Astrophysical JournalWe extend the time-dependent convection (TDC) treatment in MESA by introducing eddy-viscous dissipation. This software change brings MESA-TDC into closer alignment with the radial stellar pulsation (RSP) framework of the MESA-RSP module.
Ebraheem Farag +7 more
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