Results 41 to 50 of about 16,720 (245)

Predicting large-scale cosmological structure evolution with generative adversarial network-based autoencoders

Astronomy & Astrophysics
Predicting the nonlinear evolution of cosmic structure from initial conditions is typically approached using Lagrangian, particle-based methods. These techniques excel in terms of tracking individual trajectories, but they might not be suitable for ...
Ullmo Marion, Aghanim Nabila, Decelle Aurélien, Aragon-Calvo Miguel   +3 more
doaj   +1 more source

Variation in loss of immunity shapes influenza epidemics and the impact of vaccination

BMC Infectious Diseases, 2017
Background Protective antibody immunity against the influenza A virus wanes in 2–7 years due to antigenic drift of the virus’ surface proteins. The duration of immune protection is highly variable because antigenic evolution of the virus is irregular ...
Rutger G. Woolthuis, Jacco Wallinga, Michiel van Boven   +2 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Fiber-reinforced concrete for complex engineering conditions: material properties, nonlinear response and sustainable applications in spaceflight

High Temperature Materials and Processes
As space missions evolve toward longer durations and deeper missions, structural materials face unprecedented challenges in extreme extraterrestrial environments, such as extreme temperature swings, intense radiation, cyclic loading, and crack ...
Liu Junyu, Liu Xi
doaj   +1 more source

Topological properties of the solution set of a class of nonlinear evolutions inclusions [PDF]

Czechoslovak Mathematical Journal, 1997
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Market Typology and Dynamics of Economic Growth [PDF]

Problemi Ekonomiki
It is found that the diversity of the economy’s market (perfect competition, monopoly, oligopoly, and monopolistic competition) serves as a key to endogenous adaptation in studying economic evolution through computer modeling.
Poznyak Sergii P. , Kolyada Yurii V.
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Anti-periodic extremal problems for a class of nonlinear evolution inclusions in R N [PDF]

Journal of Inequalities and Applications, 2014
From the abstract: ``The aim of this paper is to establish the existence of anti-periodic solutions to the following nonlinear anti-periodic problem: \[ \begin{gathered}\dot{x}+A(t,x)\in Ext F(t,x) \text{ a.e. } t\in I, \\ x(T)=-x(0)\end{gathered} \] in \(\mathbb R^n\), where \(Ext F(t,x)\) denotes the extremal point set of the multifunction \(F(t,x)\),
Zhang, Jingrui, Cheng, Yi, Li, Cuiying, Hua, Hongtu   +3 more
openaire   +2 more sources

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source