Results 41 to 50 of about 16,692 (242)

Anti-periodic solutions for nonlinear evolution inclusions

Journal of Evolution Equations, 2018
The authors consider the nonlinear anti-periodic evolution inclusion \[ \begin{aligned} & -u'(t)\in A(t,u(t))+F(t,u(t))\text{ a.e. on }I=[0,T],\\ & u(0)=-u(T),\end{aligned}\eqno{(1)} \] where \(\left( X,H,X^{\ast }\right) \) is an evolution triple, \(A:I\times X\rightarrow 2^{X^{\ast }}\) and \(F:I\times X\rightarrow 2^{H}\). \ It is not assumed that \(
Gasiński, Leszek, Papageorgiou, Nikolaos S.   +1 more
openaire   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Variation in loss of immunity shapes influenza epidemics and the impact of vaccination

BMC Infectious Diseases, 2017
Background Protective antibody immunity against the influenza A virus wanes in 2–7 years due to antigenic drift of the virus’ surface proteins. The duration of immune protection is highly variable because antigenic evolution of the virus is irregular ...
Rutger G. Woolthuis, Jacco Wallinga, Michiel van Boven   +2 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

On the “bang-bang” principle for nonlinear evolution inclusions

Aequationes Mathematicae, 1993
This paper appears to be (verbatim) the same as [Aequationes Math. 45, No. 2-3, 267-280 (1993) see the review above].
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Existence and convergence theorems for evolutionary hemivariational inequalities of second order

Electronic Journal of Differential Equations, 2015
This article concerns with a class of evolutionary hemivariational inequalities in the framework of evolution triple. Based on the Rothe method, monotonicity-compactness technique and the properties of Clarke's generalized derivative and gradient, the
Zijia Peng, Cuie Xiao
doaj  

Numerical modeling of wave turbulence: Stability analysis and energy spectrum evolution

AIP Advances
This study investigates wave turbulence in fluids using a one-dimensional coupled model equation derived from conservation laws. Numerical simulations employing pseudo-spectral and finite difference methods reveal the intricate dynamics of turbulence ...
Praveen Kumar, R. Uma, R. P. Sharma
doaj   +1 more source

Predicting large-scale cosmological structure evolution with generative adversarial network-based autoencoders

Astronomy & Astrophysics
Predicting the nonlinear evolution of cosmic structure from initial conditions is typically approached using Lagrangian, particle-based methods. These techniques excel in terms of tracking individual trajectories, but they might not be suitable for ...
Ullmo Marion, Aghanim Nabila, Decelle Aurélien, Aragon-Calvo Miguel   +3 more
doaj   +1 more source

Market Typology and Dynamics of Economic Growth [PDF]

Problemi Ekonomiki
It is found that the diversity of the economy’s market (perfect competition, monopoly, oligopoly, and monopolistic competition) serves as a key to endogenous adaptation in studying economic evolution through computer modeling.
Poznyak Sergii P. , Kolyada Yurii V.
doaj   +1 more source