Results 31 to 40 of about 16,720 (245)

Anti-periodic solutions for nonlinear evolution inclusions

Journal of Evolution Equations, 2018
The authors consider the nonlinear anti-periodic evolution inclusion \[ \begin{aligned} & -u'(t)\in A(t,u(t))+F(t,u(t))\text{ a.e. on }I=[0,T],\\ & u(0)=-u(T),\end{aligned}\eqno{(1)} \] where \(\left( X,H,X^{\ast }\right) \) is an evolution triple, \(A:I\times X\rightarrow 2^{X^{\ast }}\) and \(F:I\times X\rightarrow 2^{H}\). \ It is not assumed that \(
Gasiński, Leszek, Papageorgiou, Nikolaos S.   +1 more
openaire   +2 more sources

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

On the “bang-bang” principle for nonlinear evolution inclusions

Aequationes Mathematicae, 1993
This paper appears to be (verbatim) the same as [Aequationes Math. 45, No. 2-3, 267-280 (1993) see the review above].
openaire   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Existence and convergence theorems for evolutionary hemivariational inequalities of second order

Electronic Journal of Differential Equations, 2015
This article concerns with a class of evolutionary hemivariational inequalities in the framework of evolution triple. Based on the Rothe method, monotonicity-compactness technique and the properties of Clarke's generalized derivative and gradient, the
Zijia Peng, Cuie Xiao
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Numerical modeling of wave turbulence: Stability analysis and energy spectrum evolution

AIP Advances
This study investigates wave turbulence in fluids using a one-dimensional coupled model equation derived from conservation laws. Numerical simulations employing pseudo-spectral and finite difference methods reveal the intricate dynamics of turbulence ...
Praveen Kumar, R. Uma, R. P. Sharma
doaj   +1 more source

On the set of solutions of a class of nonlinear evolution inclusions [PDF]

Kodai Mathematical Journal, 1992
The present paper deals with properties of the solution set of the Cauchy problem for nonlinear evolution inclusions of the form \(x'(t)\in A(t,x(t))+f(t)\), a.e., and \(x'(t)\in A(t,x(t))+F(t,x(t))\), a.e., where \(A\) and \(F\) are multivalued mappings.
openaire   +2 more sources

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Non-degenerate implicit evolution inclusions

Electronic Journal of Differential Equations, 2000
We prove the existence of solutions for the implicit evolution inclusion $$ ( B(t) u( t) ) ' + A(t,u(t)) i f(t) $$ under conditions that are easy to verify on the set valued operator $A( t,cdot)$ and that do not imply the operator is monotone.
Kenneth Kuttler
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