Results 31 to 40 of about 27,060 (266)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Hurricane Wave Loads on Spar-Type Floating Wind Turbines: A Comparison of Simulation Schemes
Atmosphere, 2023 Floating wind turbines are sensitive to hurricane events. Since the turbine rotors are parked and the blades are feathered during hurricanes, the aerodynamic loads due to boundary-layer winds are relatively small compared to the hydrodynamic loads due to
Shaopeng Li, Teng Wu
doaj +1 more source
Constant Rate of Loading Nonlinear Consolidation
Soils and Foundations, 1985 ABSTRACT A solution of the problem of one dimensional nonlinear consolidation under constant rate of loading is presented. The computed results of excess pore pressure in the sample are compared with those obtained by the linear theory. A new dimensionless parameter is shown to influence the magnitude of difference between linear and nonlinear ...
openaire +2 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Non-Linearity Effects of Industrial Loads on Induction Motor Servo Drive System
Iranian Journal of Electrical and Electronic Engineering, 2022 In the new advanced drive schemes, identification and modeling of the load complex characteristics can play an important role to predict the dynamic performance of the proposed control strategy. The novelty of this paper consists in the classification of
H. Azizi Moghaddam +2 more
doaj
New approach to modeling the nonlinear loads [PDF]
E3S Web of Conferences, 2019 Parameters of operating conditions of electric power systems shall ensure efficient and reliable operation of both power generating companies and of consumers, which to a great extent depends on power quality.
Kovernikova L.I., Luong Van Chung
doaj +1 more source
Beam Loading in the Nonlinear Regime of Plasma-Based Acceleration [PDF]
Physical Review Letters, 2008 A theory that describes how to load negative charge into a nonlinear, three-dimensional plasma wakefield is presented. In this regime, a laser or an electron beam blows out the plasma electrons and creates a nearly spherical ion channel, which is modified by the presence of the beam load.
Tzoufras, M. +8 more
openaire +3 more sources
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Micromachines, 2022 This paper presents a nonlinear vibration analysis of functionally graded simply supported fluid-conveying microtubes subjected to transverse excitation loads.
Tao Ma, Anle Mu
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source