Results 41 to 50 of about 3,486,102 (302)

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Nonlinear distributionally robust optimization

Mathematical Programming
This article focuses on a class of distributionally robust optimization (DRO) problems where, unlike the growing body of the literature, the objective function is potentially nonlinear in the distribution. Existing methods to optimize nonlinear functions in probability space use the Frechet derivatives, which present theoretical and computational ...
Mohammed Rayyan Sheriff, Peyman Mohajerin Esfahani   +1 more
openaire   +5 more sources

Nonlinear Analysis and Optimization with Applications [PDF]

, 2022
Nonlinear analysis has wide and significant applications in many areas of mathematics, including functional analysis, variational analysis, nonlinear optimization, convex analysis, nonlinear ordinary and partial differential equations, dynamical system ...

core   +1 more source

Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora

FEBS Open Bio, EarlyView.
This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi, Alain Dolla, Frauke Baymann, Celine Rommevaux, Latifa Elantak, Helene Gaussier, Matthieu Nouailler   +6 more
wiley   +1 more source

Generalized Implicit Set-Valued Variational Inclusion Problem with ⊕ Operation

Mathematics, 2019
In this paper, we consider a resolvent operator which depends on the composition of two mappings with ⊕ operation. We prove some of the properties of the resolvent operator, that is, that it is single-valued as well as Lipschitz-type-continuous. An
Rais Ahmad, Imran Ali, Saddam Husain, A. Latif, Ching-Feng Wen   +4 more
doaj   +1 more source

Identification of nonlinear systems using generalized kernel models

, 2005
Nonlinear system identification is considered using a generalized kernel regression model. Unlike the standard kernel model, which employs a fixed common variance for all the kernel regressors, each kernel regressor in the generalized kernel model has an
Wang, X. X., Harris, C. J., Wang, X.X., Hong, X., Harris, C.J., Chen, S., null Xunxian Wang, null Sheng Chen, C.J. Harris, null Xia Hong   +9 more
core   +1 more source

Predictive Value of Composite Inflammatory Markers for Stroke Prognosis: A Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Novel composite inflammatory markers' role in stroke prognosis is understudied, and the best predictor is unclear, requiring further exploration. Objectives This study aimed to systematically evaluate the associations of 6 novel composite inflammatory markers on stroke prognosis.
Bing Wu, Jie‐Jie Li, Jing Jing, Jin‐Xi Lin, Xia Meng, Yong Jiang, Yong‐Jun Wang, Hong‐Qiu Gu   +7 more
wiley   +1 more source

Optimizing Operations Sequencing and Demulsifier Injection in Offshore Oil Production Platforms

IEEE Access, 2023
Short-term production optimization of oil assets concerns routing decisions and equipment control settings that induce optimal steady-state operations. Typically, the decisions are made on the scale of hours to days with the aim of maximizing short-term ...
Eduardo Rauh Muller, Eduardo Camponogara, Laio Oriel Seman, Bruno Ferreira Vieira, Luis Kin Miyatake   +4 more
doaj   +1 more source

Large Scale Nonlinear Optimization

, 2006
Proceedings of the Int. School of Mathematics G.
DI PILLO, Gianni, Roma M., DI Pillo G., Roma, Massimo, Pillo, Gianni Di   +4 more
core   +1 more source