Results 21 to 30 of about 299,324 (278)

A Mean-Risk Multi-Period Optimization Model for Cooperative Risk in the Shipbuilding Supply Chain

Mathematical and Computational Applications
This study addresses the cooperative development problem between shipbuilding enterprises and suppliers under supply risk by improving and optimizing the Markowitz model.
Ziquan Xiang, Muhammad Hamza Naseem, Xiuqian Pan, Fatima Sayeeda Ahmad   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Adjoint-based predictor-corrector sequential convex programming for parametric nonlinear optimization [PDF]

, 2011
This paper proposes an algorithmic framework for solving parametric optimization problems which we call adjoint-based predictor-corrector sequential convex programming.
Diehl, M., Dinh, Q. Tran, Savorgnan, C.
core  

Mathematical Programming Decoding of Binary Linear Codes: Theory and Algorithms

, 2014
Mathematical programming is a branch of applied mathematics and has recently been used to derive new decoding approaches, challenging established but often heuristic algorithms based on iterative message passing.
Helmling, Michael, Ruzika, Stefan, Tanatmis, Akin   +2 more
core   +1 more source

A new approach to secure economic power dispatch [PDF]

, 1998
This article presents a new nonlinear convex network flow programming model and algorithm for solving the on-line economic power dispatch with N and N−1 security.
Irving, MR, Xu, GY, Zhu, JZ
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Nonlinear Mathematical Programming in Engineering Applications [PDF]

Transactions of the VŠB-Technical University of Ostrava, Mechanical Series, 2010
This paper deals with suitable nonlinear optimization in engineering applications via mathematical programming. This tool is used for optimization and control of production of steel slabs and inverse tasks, such as determination of boundary conditions ...
Tomáš MAUDER
doaj  

Optimality Condition and Wolfe Duality for Invex Interval-Valued Nonlinear Programming Problems

Journal of Applied Mathematics, 2013
The concepts of preinvex and invex are extended to the interval-valued functions. Under the assumption of invexity, the Karush-Kuhn-Tucker optimality sufficient and necessary conditions for interval-valued nonlinear programming problems are derived ...
Jianke Zhang
doaj   +1 more source

Planning a Continuous Vehicle Trajectory for an Automated Lane Change Maneuver by Nonlinear Programming considering Car-Following Rule and Curved Roads

Journal of Advanced Transportation, 2020
This study proposes a trajectory planning method for an automated lane change maneuver. We consider that the spatiotemporal trajectory of a controlled vehicle can be represented by a polynomial function and estimate the parameters of the polynomial ...
Chong Wei, Shurong Li
doaj   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source