Results 31 to 40 of about 53,074 (307)

Scheduling jobs with time-resource tradeoff via nonlinear programming [PDF]

, 2008
We consider a scheduling problem where the processing time of any job is dependent on the usage of a discrete renewable resource, e.g. personnel. An amount of k units of that resource can be allocated to the jobs at any time, and the more of that ...
Uetz, Marc, Uetz, M.J., Grigoriev, Alexander, Alexander Grigoriev, Grigoriev, A., Marc Uetz, Grigoriev, A.; id_orcid, Uetz, Marc Jochen   +7 more
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

A Comparison of Normal Cone Conditions for Homotopy Methods for Solving Inequality Constrained Nonlinear Programming Problems

Advances in Mathematical Physics, 2020
Homotopy methods are powerful tools for solving nonlinear programming. Their global convergence can be generally established under conditions of the nonemptiness and boundness of the interior of the feasible set, the Positive Linear Independent ...
Zhengyong Zhou, Ting Zhang
doaj   +1 more source

Non-convex mixed-integer nonlinear programming : a survey [PDF]

, 2012
A wide range of problems arising in practical applications can be formulated as Mixed-Integer Nonlinear Programs (MINLPs). For the case in which the objective and constraint functions are convex, some quite effective exact and heuristic algorithms are ...
Burer, S, Letchford, Adam, Adam N. Letchford, Samuel Burer   +3 more
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Uniqueness of solutions and Ulam–Hyers–Mittag-Leffler stability for Hammerstein-type Hilfer delay differential equations of fractional order

Nonlinear Engineering
In this paper, we discuss the existence of a unique solution and Ulam–Hyers–Mittag-Leffler (UHML) stability for a nonlinear Hammerstein-type ψ-Hilfer delay differential equation of fractional order (ψ-HFDDE) in the configuration of several variable time ...
Tunҫ Cemil, Ahmad Bashir, Tunҫ Osman
doaj   +1 more source

A Mean-Risk Multi-Period Optimization Model for Cooperative Risk in the Shipbuilding Supply Chain

Mathematical and Computational Applications
This study addresses the cooperative development problem between shipbuilding enterprises and suppliers under supply risk by improving and optimizing the Markowitz model.
Ziquan Xiang, Muhammad Hamza Naseem, Xiuqian Pan, Fatima Sayeeda Ahmad   +3 more
doaj   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

A Q‐Learning Algorithm to Solve the Two‐Player Zero‐Sum Game Problem for Nonlinear Systems

International Journal of Adaptive Control and Signal Processing, Volume 39, Issue 3, Page 566-581, March 2025.
A Q‐learning algorithm to solve the two‐player zero‐sum game problem for nonlinear systems. ABSTRACT This paper deals with the two‐player zero‐sum game problem, which is a bounded L2$$ {L}_2 $$‐gain robust control problem. Finding an analytical solution to the complex Hamilton‐Jacobi‐Issacs (HJI) equation is a challenging task.
Afreen Islam, Anthony Siming Chen, Guido Herrmann   +2 more
wiley   +1 more source

Characterization of Defect Distribution in an Additively Manufactured AlSi10Mg as a Function of Processing Parameters and Correlations with Extreme Value Statistics

Advanced Engineering Materials, EarlyView.
Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt, Varma Kvvssn, Hossein Laieghi, Zia Uddin, Peyman Ansari, E. Kıvanç Sadak, Can Barış Toprak, Hüseyin Kızıl, Enrico Salvati   +8 more
wiley   +1 more source