Results 31 to 40 of about 31,125 (259)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Uniqueness of solutions and Ulam–Hyers–Mittag-Leffler stability for Hammerstein-type Hilfer delay differential equations of fractional order

Nonlinear Engineering
In this paper, we discuss the existence of a unique solution and Ulam–Hyers–Mittag-Leffler (UHML) stability for a nonlinear Hammerstein-type ψ-Hilfer delay differential equation of fractional order (ψ-HFDDE) in the configuration of several variable time ...
Tunҫ Cemil, Ahmad Bashir, Tunҫ Osman
doaj   +1 more source

A Mean-Risk Multi-Period Optimization Model for Cooperative Risk in the Shipbuilding Supply Chain

Mathematical and Computational Applications
This study addresses the cooperative development problem between shipbuilding enterprises and suppliers under supply risk by improving and optimizing the Markowitz model.
Ziquan Xiang, Muhammad Hamza Naseem, Xiuqian Pan, Fatima Sayeeda Ahmad   +3 more
doaj   +1 more source

A Comparison of Normal Cone Conditions for Homotopy Methods for Solving Inequality Constrained Nonlinear Programming Problems

Advances in Mathematical Physics, 2020
Homotopy methods are powerful tools for solving nonlinear programming. Their global convergence can be generally established under conditions of the nonemptiness and boundness of the interior of the feasible set, the Positive Linear Independent ...
Zhengyong Zhou, Ting Zhang
doaj   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

Clinical and Modifiable Factors Associated With Disability and Relapse in MOGAD: A Multicentre Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Factors associated with relapse course and disability in myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) remain incompletely understood. Objectives To identify clinical and modifiable factors associated with relapse and disability in MOGAD. Methods In this ambispective multicentre cohort study using data from
Yingtao Wang, Shaoxin Tao, Qiujia Wang, Xiaoyu Xu, Hui Yao, Zheng Liu, Dawei Li, Zhandong Qiu, Jinming Han, Jiangwei Xia, Qi Wang, Jun Sun, Kai Shao, Jiao Li, Shishuang Ruan, Yi Zhong, Jun Guo, Shougang Guo, Yue Huang, Guoliang Chai, Tao Jin, Hongyu Zhou, Junwei Hao, Yinan Zhao   +23 more
wiley   +1 more source

Predictive Value of Composite Inflammatory Markers for Stroke Prognosis: A Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Novel composite inflammatory markers' role in stroke prognosis is understudied, and the best predictor is unclear, requiring further exploration. Objectives This study aimed to systematically evaluate the associations of 6 novel composite inflammatory markers on stroke prognosis.
Bing Wu, Jie‐Jie Li, Jing Jing, Jin‐Xi Lin, Xia Meng, Yong Jiang, Yong‐Jun Wang, Hong‐Qiu Gu   +7 more
wiley   +1 more source

A Novel Reduced-Order Analytical Fault Diagnosis Model for Power Grid

IEEE Access
Power grid fault diagnosis methods based on analytical models possess advantages such as logical rigor, strong interpretability, and high applicability.
Zhuonan Lin, Yongxing Wang, Haoqian Xu, Fanrong Wei   +3 more
doaj   +1 more source

Nonlinear Mathematical Programming in Engineering Applications [PDF]

Transactions of the VŠB-Technical University of Ostrava, Mechanical Series, 2010
This paper deals with suitable nonlinear optimization in engineering applications via mathematical programming. This tool is used for optimization and control of production of steel slabs and inverse tasks, such as determination of boundary conditions ...
Tomáš MAUDER
doaj