Results 31 to 40 of about 8,662,373 (247)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Nonlinear Site Response Analysis in District XIII, Budapest

Slovak Journal of Civil Engineering
Urban seismic hazard assessments must account for local soil conditions that can significantly alter ground motion characteristics. This study presents a nonlinear one-dimensional (1D) site response analysis for four locations within Budapest’s District ...
Al-Azazmeh Ahmad, Mahler András
doaj   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

Predictive Value of Composite Inflammatory Markers for Stroke Prognosis: A Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Novel composite inflammatory markers' role in stroke prognosis is understudied, and the best predictor is unclear, requiring further exploration. Objectives This study aimed to systematically evaluate the associations of 6 novel composite inflammatory markers on stroke prognosis.
Bing Wu, Jie‐Jie Li, Jing Jing, Jin‐Xi Lin, Xia Meng, Yong Jiang, Yong‐Jun Wang, Hong‐Qiu Gu   +7 more
wiley   +1 more source

Simulation of the In Situ Spatially Varying Ground Motions and Nonlinear Seismic Response Analysis of the Cable-Stayed Bridge

Shock and Vibration, 2020
To study the nonlinear seismic behavior and seismic resistance of the long-span cable-stayed bridges subjected to earthquakes, the multidimensional and multisupported artificial ground motions are synthesized first based on the in situ site conditions of
Jin Zhang, Ke-jian Chen, Neng-pan Ju, Shi-xiong Zheng, Hong-yu Jia, Da-ping Yuan   +5 more
doaj   +1 more source

Nonlinear numerical simulation of dynamic response of pile site and pile foundation under earthquake

Nonlinear Engineering, 2022
To study the influence of the nonlinear connection of pile and soil on the dynamic response characteristics of the pile foundation, this article proposes to study the dynamic response of the bridge pile foundation to the slope by combining the ...
Liang Wenwen, Leng Lingye, Tian Hao, Tian Xiao   +3 more
doaj   +1 more source

Gravity‐Dependent Modulation of Downbeat Nystagmus: Insights From Velocity‐Storage Dysfunction

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Downbeat nystagmus varies with head position, a phenomenon termed gravity‐dependent modulation. We aimed to clarify its mechanism using a velocity‐storage model. Methods In 10 patients with downbeat nystagmus due to cerebellar disorders, we recorded eye movements at different pitch‐ and roll‐axis head positions.
Ji‐Hyung Park, Eun‐Hyuk Choi, Jorge Otero‐Millan, David S. Zee, Jeong‐Yoon Choi, Ji‐Soo Kim   +5 more
wiley   +1 more source

V S30, slope, H 800 and f 0: performance of various site-condition proxies in reducing ground-motion aleatory variability and predicting nonlinear site response

Earth, Planets and Space, 2017
The aim of this paper is to investigate the ability of various site-condition proxies (SCPs) to reduce ground-motion aleatory variability and evaluate how SCPs capture nonlinearity site effects. The SCPs used here are time-averaged shear-wave velocity in
Boumédiène Derras, Pierre-Yves Bard, Fabrice Cotton   +2 more
doaj   +1 more source

SEISMIC RESPONSE ANALYSIS ON EARTHQUAKE MOTION AT ZAFARANA WIND TURBINE FARM, EGYPT [PDF]

Fayoum University Journal of Engineering, 2019
Zafarana wind turbine towers farm, which is located 120 km south of Suez on the Red Sea, lies in not only the highest wind speed zones but also the most seismically active areas.
Youssef Youssef, Gihan Abelrahman, Mohamed Abdelaziz, Khaled Mohamed   +3 more
doaj   +1 more source