Results 41 to 50 of about 216,988 (317)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Stability Problems and Analytical Integration for the Clebsch’s System

Open Mathematics, 2019
The nonlinear stability and the existence of periodic orbits of the equilibrium states of the Clebsch’s system are discussed.. Numerical integration using the Lie-Trotter integrator and the analytic approximate solutions using Multistage Optimal Homotopy
Pop Camelia, Ene Remus-Daniel
doaj   +1 more source

Design and Stability Analysis Techniques for Switching-Mode Nonlinear Circuits: Power Amplifiers and Oscillators [PDF]

, 2006
A design technique for kW level switching mode power amplifiers is presented. Several push pull pairs, independently tuned to Class E/Fodd, are combined by a distributed active transformer.
Jeon, Sanggeun
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Input-to-state stability for parameterized discrete-time time-varying nonlinear systems with applications

, 2005
Input-testate stability (ISS) of a parameterized familyof discrete-time time-varying nonlinear systems isinvestigated. A converse Lyapunov theorem for such systems is developed.
Laila, Dina Shona, Astolfi, A., Astolfi, Alessandro   +2 more
core   +1 more source

Bifurcation and stability in nonlinear discrete systems

, 2020
This book focuses on bifurcation and stability in nonlinear discrete systems, including monotonic and oscillatory stability. It presents the local monotonic and oscillatory stability and bifurcation of period-1 fixed-points on a specific eigenvector ...
Luo, Albert C J
core   +1 more source

Almost sure and moment exponential stability in the numerical simulation of stochastic differential equations [PDF]

, 2007
Relatively little is known about the ability of numerical methods for stochastic differential equations (SDEs) to reproduce almost sure and small-moment stability.
Yuan, C., Mao, X., Chenggui Yuan, Mao, Xuerong, Higham, D.J.   +4 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Nonlinear stability of shear deformable eccentrically stiffened functionally graded plates on elastic foundations with temperature-dependent properties

Science and Engineering of Composite Materials, 2017
This article investigates the nonlinear stability of eccentrically stiffened moderately thick plates made of functionally graded materials (FGM) subjected to in-plane compressive, thermo-mechanical loads.
Cong Pham Hong, Ngoc An Pham Thi, Duc Nguyen Dinh   +2 more
doaj   +1 more source

mu-stability criteria for nonlinear differential systems with additive leakage and transmission time-varying delays

, 2018
In this paper, the μ-stability analysis issue of nonlinear differential systems along with two kinds of delay components, namely, leakage delay and transmission delay, is investigated.
Rakkiyappan, Rajan, Lv, Xiaoxiao, Li, Xiaodi   +2 more
core   +1 more source