Results 41 to 50 of about 796,265 (291)

Nonlinear Stability of Eady's Model [PDF]

Journal of the Atmospheric Sciences, 1994
A nonlinear stability theorem is established for Eady's model of baroclinic flow. In particular, the Eady basic state is shown to be nonlinearly stable (for arbitrary shear) provided (Δz)/(Δy) > 2(5)^1/2f/(πN),where Δz is the height of the domain, Δy the channel width, f the Coriolis parameter, and N the buoyancy frequency.
Mu, Mu, Shepherd, Theodore G.
openaire   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Two-dimensional matter-wave solitons and vortices in competing cubic-quintic nonlinear lattices

, 2017
The nonlinear lattice---a new and nonlinear class of periodic potentials---was recently introduced to generate various nonlinear localized modes. Several attempts failed to stabilize two-dimensional (2D) solitons against their intrinsic critical collapse
Gao, Xuzhen, Zeng, Jianhua
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Stability of subdivision schemes [PDF]

, 1998
The stability of stationary interpolatory subdivision schemes for univariate data is investigated. If the subdivision scheme is linear, its stability follows from the convergence of the scheme, but for nonlinear subdivision schemes one needs stronger ...
Damme, R.M.J. van, Kuijt, F.
core   +1 more source

Stability of Spatial Optical Solitons [PDF]

, 2000
We present a brief overview of the basic concepts of the soliton stability theory and discuss some characteristic examples of the instability-induced soliton dynamics, in application to spatial optical solitons described by the NLS-type nonlinear models ...
A. Rossi, A.A. Sukhorukov, AV Buryak, AW Snyder, C Yeh, C. Et-rich, C.K.R.T. Jones, D Mihalache, D.E. Edmundson, D.J. Kaup, DE Pelinovsky, DE Pelinovsky, DE Pelinovsky, DJ Mitchell, DV Skryabin, EA Kuznetsov, EA Ostrovskaya, GI Stegeman, IV Barashenkov, J Shatah, JJ García-Ripoll, JN Malmberg, L Torner, M Grillakis, M Grillakis, M Johansson, M Mitchell, M Segev, M.M. Bogdan, MI Weinstein, N.G. Vakhitov, RW Micallef, RY Chiao, T Carmon, V Tikhonenko, VI Kruglov, W Krolikowski, WJ Firth, YA Li, YS Kivshar, YS Kivshar, YS Kivshar, YS Kivshar, YS Kivshar, ZH Musslimani, ZK Yankauskas   +45 more
core   +1 more source

Nonlinear stabilization in infinite dimension

Annual Reviews in Control, 2013
Significant advances have taken place in the last few years in the development of control designs for nonlinear infinite-dimensional systems. Such systems typically take the form of nonlinear ODEs (ordinary differential equations) with delays and nonlinear PDEs (partial differential equations).
Miroslav Krstic, Nikolaos Bekiaris-Liberis   +1 more
openaire   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Neural Nonparametric Stability Indicator for Self-Excited Dynamical Systems

IEEE Access
This article introduces a novel methodology employing deep-learning neural networks to estimate Lyapunov functions in dynamic systems accurately. Unlike traditional parametric approaches, our method is model-free, enabling adaptability to various system ...
Krzysztof Lalik
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source