Results 81 to 90 of about 4,626,700 (338)

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu   +10 more
wiley   +1 more source

Vanishing viscosity limit for a one-dimensional viscous conservation law in the presence of two noninteracting shocks

open access: yesDemonstratio Mathematica
In this article, we study the inviscid limit of the solution to the Cauchy problem of a one-dimensional viscous conservation law, where the second-order term is nonlinear. Under the assumption that the inviscid equation admits a piecewise smooth solution
Feng Li, Wang Jing
doaj   +1 more source

Pointwise convergence to a Maxwellian for a Broadwell model with a supersonic boundary

open access: yesNetworks and Heterogeneous Media, 2007
In this paper, we consider an initial-boundary value problem for the Broadwell model with a supersonic physical boundary. By using the Green’s function established in [6] and weighted energy estimates, we show that the solution converges pointwise to the
Shijin Deng, Weike Wang, Shih-Hsien Yu
doaj   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher   +10 more
wiley   +1 more source

Global and Regional Temporal Changes in Cross‐Country Inequalities of Site‐Specific Osteoarthritis Burden, 1990 to 2021

open access: yesArthritis Care &Research, EarlyView.
Objective This study examined the global and regional temporal changes in cross‐country inequalities of site‐specific osteoarthritis (OA) burden from 1990 to 2021. Methods Age‐standardized years lived with disability rates (ASYRs) for site‐specific OA across 204 countries and territories were obtained from the Global Burden of Diseases, Injuries, and ...
Haowei Chen   +14 more
wiley   +1 more source

Temporal Trends in and Associations With Nonsteroidal Anti‐inflammatory Drug Prescription in Adult and Pediatric Patients With Inflammatory Bowel Disease

open access: yesArthritis Care &Research, EarlyView.
Objective Recent inflammatory bowel disease (IBD) treatment guidelines have recommended against nonsteroidal anti‐inflammatory drug (NSAID) use despite prevalent musculoskeletal symptoms and opioid overuse in this population. Given the discordance between changing national guidelines and potential clinical utility, we sought to assess national temporal
Adam S. Mayer   +5 more
wiley   +1 more source

Sarilumab in Polyarticular‐Course Juvenile Idiopathic Arthritis: Dose‐Finding and One‐Year Analysis of a Phase 2b, Open‐Label, Multicenter Study

open access: yesArthritis Care &Research, Accepted Article.
Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension‐phase). During part 1, three doses were assessed in two weight groups (Group A/B: ≥30–60 kg/≥10–<
Fabrizio De Benedetti   +19 more
wiley   +1 more source

Nonlinear growth of zonal flows by secondary instability in general magnetic geometry

open access: yesNew Journal of Physics, 2017
We present a theory of the nonlinear growth of zonal flows in magnetized plasma turbulence, by the mechanism of secondary instability. The theory is derived for general magnetic geometry, and is thus applicable to both tokamaks and stellarators.
G G Plunk, A Bañón Navarro
doaj   +1 more source

Home - About - Disclaimer - Privacy