Results 41 to 50 of about 465,530 (295)
Haldane linearisation done right: Solving the nonlinear recombination equation the easy way
, 2016 The nonlinear recombination equation from population genetics has a long history and is notoriously difficult to solve, both in continuous and in discrete time.
Baake, Ellen, Baake, Michael
core +1 more source
IMPAβ: Incremental Modal Pushover Analysis for Bridges
Applied Sciences, 2020 In the present study, the incremental modal pushover analysis (IMPA), a pushover-based approach already proposed and applied to buildings by the same authors, was revised and proposed for bridges (IMPAβ). Pushover analysis considers the effects of higher
Alessandro Vittorio Bergami +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Cohesive zone models in history dependent materials [PDF]
, 2013 Copyright @ 2013 ACMECohesive zone model is a well known concept in nonlinear fracture mechanics of elasto-plastic materials. In contrast to that, we discuss a development of the cohesive zone model to linear, but time and history dependent, materials ...
Hakim, L, Mikhailov, SE
core +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
Nonlinear Static Procedure for Fragility Curve Development [PDF]
, 2000 This study examines the fragility curves of a bridge by two different analytical approaches; one utilizes the time-history analysis and the other uses the capacity spectrum method.
Feng, Maria Q. +3 more
core +2 more sources
The Effect of Spandrel Beam's Specification on Response Modification Factor of Concrete Coupled Shear Walls [PDF]
Civil Engineering Infrastructures Journal, 2016 Response modification factor (R factor) is one of the seismic design parameters to be considered in evaluating the performance of buildings during strong motions. This paper has tried to evaluate the response modification factor of concrete coupled shear
Mussa Mahmoudi +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Evaluating Seismic Isolation Design: Simplified Linear Methods vs. Nonlinear Time-History Analysis
DesignsSeismic isolation is a vital strategy for improving the earthquake resilience of structures, utilizing flexible components such as lead–rubber bearings (LRBs) and curved surface sliders (CSSs) to attenuate ground motion effects.
Elias Yaacoub +3 more
doaj +1 more source