Results 271 to 280 of about 2,535,217 (348)
Predicting and understanding comprehensive drug-drug interactions via semi-nonnegative matrix factorization. [PDF]
Yu H +6 more
europepmc +1 more source
On why cancer cells require a great amount of glucose
Abstract The traditional thinking has been that cancer cells require a great amount of glucose to support their rapid growth, but the reality may be different. We have previously demonstrated that all cancer cells in The Cancer Genome Atlas harbor persistent Fenton reactions in their cytosol, which generate OH− ${\text{OH}}^{-}$ and ultimately kill the
Xuechen Mu +6 more
wiley +1 more source
ABSTRACT The traditional model specification of stepped‐wedge cluster‐randomized trials assumes a homogeneous treatment effect across time while adjusting for fixed‐time effects. However, when treatment effects vary over time, the constant effect estimator may be biased.
Zhe Chen +6 more
wiley +1 more source
ABSTRACT Although homoscedasticity is often assumed in linear regression, real data may show variance patterns or residual structures that violate this assumption. We propose VarGuid, a variance‐guided framework for two related settings: Covariate‐dependent conditional variance under a global linear mean model, and residual nonlinear mean structure ...
Sibei Liu, Min Lu
wiley +1 more source
Abunmix enables the simple and robust multiplexed immunofluorescence imaging
Multiplexed fluorescence imaging is limited by bleed‐through signals arising from the use of antibodies derived from the same host species. Abunmix can separate signals from multiple antibodies generated from the same host species using a signal unmixing algorithm.
Woonggi La +14 more
wiley +1 more source
Simultaneously Modelling Occurrence and Quantity of Multivariate Semicontinuous Data
ABSTRACT Joint models have been developed recently for multivariate semicontinuous data; however, joint modelling implies structured covariance and nonnegative correlation among responses, and thus is inflexible in accommodating complex covariance structures in practice.
Xingde Duan, Renjun Ma
wiley +1 more source
Innovation Ecosystems in Catalonia: Exploring Location Patterns of High‐Tech Firms
ABSTRACT This paper analyses high‐tech firms' location determinants in Catalonia, Spain, using 2010–2019 firm data, and spatial models to assess spillover and industry‐specific factor effects. Results show that high‐tech firms, especially in services, are clustered in busy, wealthy cities with strong innovation hubs, while non‐high‐tech firms prefer ...
Keli Araujo‐Rocha +1 more
wiley +1 more source
On Measuring the Welfare Cost of Inflation
Abstract This paper uses neoclassical monetary demand theory to measure the welfare cost of inflation. It uses the microeconomic‐ and aggregation‐theoretic approach to the demand for money, that integrates the demand for money with the demands for consumption and leisure, and provides a comparison between the consumer surplus approach based on ...
APOSTOLOS SERLETIS, LIBO XU
wiley +1 more source
ABSTRACT The persistence of organisms in changing climates depends on both phenotypic plasticity and adaptation. However, despite extensive research, it remains largely unclear how forest trees will genetically adapt or phenotypically acclimate to future climates.
Aksel Pålsson +5 more
wiley +1 more source

