Decoding Transdiagnostic Subtypes in Emotional Disorders. [PDF]
Using nonnegative matrix factorization (NMF) clustering, our transdiagnostic study identified five representative functional networks (RFNs) that capture the heterogeneity of emotional disorders. These RFNs delineated five clinically distinct subtypes, each with unique diagnostic proportions, clinical symptomatology, and brain functional and structural
Wu Y +5 more
europepmc +2 more sources
Deep-Learning-Driven High-Fidelity In Vivo Hyperspectral Fluorescence Imaging Under Extreme Photon-Limited Conditions. [PDF]
Highly overlapping fluorescent signals become distinguishable in photon‐limited living organisms via advanced imaging with intelligent reconstruction. The resulting in vivo hyperspectral imaging capability reveals nanoplastic uptake and circulation in live zebrafish, providing a new approach for studying complex biological and environmental processes ...
Li R +11 more
europepmc +2 more sources
Diagnosing Anaerobic Digesters' Function and Performance: From Meta-Omics to Integrated Meta-Omics Analyses. [PDF]
The integration of multiple meta‐omics can tremendously improve our understanding of the structure, function and dynamics of the complex biological system in anaerobic digesters. Created in BioRender. https://BioRender.com/u9rj8ko. ABSTRACT Anaerobic digestion (AD) of organic wastes by microorganisms into biomethane contributes significantly towards ...
Ehiosun KI, Chapleur O, Mazéas L.
europepmc +2 more sources
Single‐Cell Multiomics Reveals That OTUD7B Is a Central Driver of Epithelial Remodelling and the Immunosuppressive Microenvironment in Pancreatic Ductal Adenocarcinoma [PDF]
ABSTRACT Pancreatic ductal adenocarcinoma (PAAD) is characterized by extreme malignancy and profound resistance to therapy, largely driven by a fibrotic and immunosuppressive tumour microenvironment (TME). The deubiquitinase OTU domain‐containing protein 7B (OTUD7B) has been implicated in inflammatory and oncogenic signalling, but its role in PAAD and ...
Liu X +4 more
europepmc +2 more sources
Generalized Separable Nonnegative Matrix Factorization Algorithm Based on Orthogonal Constraints [PDF]
Separable Nonnegative Matrix Factorization(NMF) is a special NMF method used to represent an entire dataset by extracting partial samples or key topics from the dataset.Generalized Separable Nonnegative Matrix Factorization(GSNMF) is an extended ...
Junhang CHEN, Zuyuan YANG, Mingyang LIU, Lingjiang LI
doaj +1 more source
Sparsity-Constrained Coupled Nonnegative Matrix–Tensor Factorization for Hyperspectral Unmixing
Hyperspectral unmixing refers to a source separation problem of decomposing a hyperspectral imagery (HSI) to estimate endmembers, and their corresponding abundances.
Heng-Chao Li +3 more
doaj +1 more source
Hyperspectral spectral mixture analysis (SMA), which intends to decompose mixed pixels into a collection of endmembers weighted by their corresponding fraction abundances, has been successfully used to tackle mixed-pixel problem in hyperspectral remote ...
Ge Zhang, Shaohui Mei, Yan Feng, Qian Du
doaj +1 more source
Nonnegative matrix factorization (NMF), which is aimed at making all elements of the factorization nonnegative and achieving nonlinear dimensional reduction at the same time, is an effective method for solving recommendation system problems. However, in many real‐world applications, most models learn recommendation models under the supervised learning ...
Ronghua Zhang +5 more
openaire +1 more source
Adaptive Kernel Graph Nonnegative Matrix Factorization
Nonnegative matrix factorization (NMF) is an efficient method for feature learning in the field of machine learning and data mining. To investigate the nonlinear characteristics of datasets, kernel-method-based NMF (KNMF) and its graph-regularized ...
Rui-Yu Li, Yu Guo, Bin Zhang
doaj +1 more source
Adaptive computation of the Symmetric Nonnegative Matrix Factorization (SymNMF)
Nonnegative Matrix Factorization (NMF), first proposed in 1994 for data analysis, has received successively much attention in a great variety of contexts such as data mining, text clustering, computer vision, bioinformatics, etc. In this paper the case of a symmetric matrix is considered and the symmetric nonnegative matrix factorization (SymNMF) is ...
P. Favati +3 more
openaire +3 more sources

