Results 51 to 60 of about 2,151 (154)

Impact of the Choice of Normalization Method on Molecular Cancer Class Discovery Using Nonnegative Matrix Factorization. [PDF]

PLoS ONE, 2016
Nonnegative Matrix Factorization (NMF) has proved to be an effective method for unsupervised clustering analysis of gene expression data. By the nonnegativity constraint, NMF provides a decomposition of the data matrix into two matrices that have been ...
Haixuan Yang, Cathal Seoighe
doaj   +1 more source

Latent Multi-View Semi-Nonnegative Matrix Factorization with Block Diagonal Constraint

Axioms, 2022
Multi-view clustering algorithms based on matrix factorization have gained enormous development in recent years. Although these algorithms have gained impressive results, they typically neglect the spatial structures that the latent data representation ...
Lin Yuan, Xiaofei Yang, Zhiwei Xing, Yingcang Ma   +3 more
doaj   +1 more source

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, Volume 13, Issue 38, 9 July 2026.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

Bioanalytical TERS and Advanced Data Processing Methods

Journal of Raman Spectroscopy, Volume 57, Issue 6, Page 977-994, June 2026.
Tip‐enhanced Raman spectroscopy delivers label‐free, subnanometer vibrational imaging of biological systems. Recent advances in instrumentation, data analysis, and ambient/liquid operation enable surface‐selective mapping of molecular heterogeneity in proteins, nucleic acids, membranes, and viruses, positioning TERS as a powerful platform for nanoscale
Sarika Joshi, Ankit Dodla, Sarthak Saxena, Twinkle Soni, Sumit Saxena, Shobha Shukla, Bayden R. Wood   +6 more
wiley   +1 more source

Model-Based Method for Acoustic Echo Cancelation and Near-End Speaker Extraction: Non-negative Matrix Factorization

Journal of Telecommunications and Information Technology, 2018
Rapid escalation of wireless communication and hands-free telephony creates a problem with acoustic echo in full-duplex communication applications. In this paper a simulation of model-based acoustic echo cancelation and near-end speaker extraction using
Pallavi Agrawal, Madhu Shandilya
doaj   +1 more source

Loss of VMP1 Impairs Tight Junction Recycling and Aggravates Intestinal Barrier Dysfunction in Inflammatory Bowel Disease

Advanced Science, Volume 13, Issue 25, 4 May 2026.
This study identifies vacuole membrane protein 1 (VMP1) as a critical regulator of intestinal epithelial barrier homeostasis. VMP1 facilitates the recruitment of CORO1C to late endosomes, supporting Retromer‐mediated recycling of the tight junction protein Occludin.
Jiawei Zhao, Jianjun Zou, Chen Zhou, Yingui Wang, Yiman Liu, Yanqing Zhou, Yuxiang Wang, Xinyu Zhang, Huishu Yang, Hongjie Yin, Dongsheng Bai, Yue Zhao, Na Lu   +12 more
wiley   +1 more source

Niacin promotes motor function recovery after spinal cord injury via Hcar2‐dependent microglia immunometabolic regulation

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
• The activation of the microglial Hcar2 receptor by niacin initiates intracellular signalling that induces metabolic reprogramming. • This metabolic shift is characterized by increased oxidative phosphorylation. Consequently, microglia polarize from a proinflammatory state toward an anti‐inflammatory, reparative phenotype.
Hua Du, Lingnian Zeng, Chan Liu, Huyao Zhou, Xia Wang, Qing Ai, Jinpiao Zhu, Nong Xiao   +7 more
wiley   +1 more source

Symmetric Nonnegative Matrix Factorization Based on Box-Constrained Half-Quadratic Optimization

IEEE Access, 2020
Nonnegative Matrix Factorization (NMF) based on half-quadratic (HQ) functions was proven effective and robust when dealing with data contaminated by continuous occlusion according to the half-quadratic optimization theory.
Bo-Wei Chen
doaj   +1 more source

A Bayesian Causal Model for Matrix‐Valued Exposures With Applications to Radiotherapy Planning

Statistics in Medicine, Volume 45, Issue 10-12, May 2026.
ABSTRACT In radiotherapy for cancer, organs surrounding the target tumor, known as organs‐at‐risk (OARs), should be protected from excessive radiation to avoid toxicity. Radiation exposure to multiple OARs can be summarized using matrix‐valued dose‐volume histograms (DVH), and understanding the causal relationship between DVHs and toxicity outcomes can
Zijin Liu, Zhihui (Amy) Liu, Jennifer Dang, Charles Catton, Himanshu R. Lukka, Peter Chung, Olli Saarela   +6 more
wiley   +1 more source

Uncovering Immune Niches in Health and Disease Using Spatial Transcriptomics

European Journal of Immunology, Volume 56, Issue 4, April 2026.
Through the lens of spatial transcriptomics and associated tools, novel immune niche constituents can now be resolved. Drawing on gut and tumor contexts, we propose a framework to define immune niches and integrate clonal dynamics, aiming to advance niche‐directed therapies toward precise, context‐specific immune modulation.
Johan Thorsson, Yang Zhao, Eduardo J. Villablanca, Camilla Engblom   +3 more
wiley   +1 more source