Results 61 to 70 of about 1,628,183 (185)

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, Volume 13, Issue 45, 13 August 2026.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

Categorical Dimensions of Human Odor Descriptor Space Revealed by Non-Negative Matrix Factorization [PDF]

, 2013
In contrast to most other sensory modalities, the basic perceptual dimensions of olfaction remain unclear. Here, we use non-negative matrix factorization (NMF) – a dimensionality reduction technique – to uncover structure in a panel of odor profiles ...
Castro, Jason B., Jason B. Castro, Castro, Jason B, Chennubhotla, Chakra S., Ramanathan, Arvind, Schaefer, Andreas, Chennubhotla Chakra S., Arvind Ramanathan (198127), Jason B. Castro (460485), Jason B Castro, Ramanathan Arvind, Arvind Ramanathan, Castro Jason B., Chakra S. Chennubhotla, Chennubhotla, Chakra S, Chakra S Chennubhotla, Chakra S. Chennubhotla (232086)   +16 more
core   +2 more sources

Nonnegative Unimodal Matrix Factorization

, 2021
We introduce a new Nonnegative Matrix Factorization (NMF) model called Nonnegative Unimodal Matrix Factorization (NuMF), which adds on top of NMF the unimodal condition on the columns of the basis matrix. NuMF finds applications for example in analytical
Andersen Man Shun Ang, Vandaele, Arnaud, Arnaud Vandaele, Hans De Sterck, Ang, Andersen Man Shun, Sterck, Hans De, Nicolas Gillis, Gillis, Nicolas   +7 more
core   +1 more source

Latent Multi-View Semi-Nonnegative Matrix Factorization with Block Diagonal Constraint

Axioms, 2022
Multi-view clustering algorithms based on matrix factorization have gained enormous development in recent years. Although these algorithms have gained impressive results, they typically neglect the spatial structures that the latent data representation ...
Lin Yuan, Xiaofei Yang, Zhiwei Xing, Yingcang Ma   +3 more
doaj   +1 more source

SMILE: Extraction‐free submicron‐resolution mapping of lipid chain length and unsaturation by stimulated Raman imaging

VIEW, Volume 7, Issue 4, August 2026.
In this work, we develop submicron‐resolution mapping of intracellular lipid elements (SMILE) as an extraction‐free vibrational spectroscopic imaging platform based on hyperspectral stimulated Raman scattering microscopy with a spectral analysis pipeline for pixel‐resolved lipid profiling.
Yihui Zhou, Xiangjie Huang, Xingxin Liu, Ling Zhang, Jie Huang, Jing Zhao, Yongqing Zhang, Jin Zhang, Yanqing Gong, Delong Zhang, Hyeon Jeong Lee   +10 more
wiley   +1 more source

Model-Based Method for Acoustic Echo Cancelation and Near-End Speaker Extraction: Non-negative Matrix Factorization

Journal of Telecommunications and Information Technology, 2018
Rapid escalation of wireless communication and hands-free telephony creates a problem with acoustic echo in full-duplex communication applications. In this paper a simulation of model-based acoustic echo cancelation and near-end speaker extraction using
Pallavi Agrawal, Madhu Shandilya
doaj   +1 more source

Simplex‐based model for nanoparticle grain identification in four‐dimensional scanning transmission electron microscopy data

Journal of Microscopy, Volume 303, Issue 2, Page 194-215, August 2026.
Abstract Grain identification in polycrystalline nanoparticles, for example, determining which crystal phases are present at each spatial location, is fundamental to materials characterisation. This is particularly challenging when grains overlap extensively, as commonly occurs in four‐dimensional scanning transmission electron microscopy (4D‐STEM ...
Wei Liu, Roberto dos Reis, Chad A. Mirkin, Vinayak P. Dravid, Wei Chen, Daniel W. Apley   +5 more
wiley   +1 more source

Fast Parallel Randomized Algorithm for Nonnegative Matrix Factorization with KL Divergence for Large Sparse Datasets [PDF]

, 2016
Nonnegative Matrix Factorization (NMF) with Kullback-Leibler Divergence (NMF-KL) is one of the most significant NMF problems and equivalent to Probabilistic Latent Semantic Indexing (PLSI), which has been successfully applied in many applications.
Ho, Tu-Bao, Nguyen, Duy-Khuong
core   +1 more source

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, Volume 13, Issue 38, 9 July 2026.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

Sequentially-fit alternating least squares algorithms in nonnegative matrix factorization [PDF]

, 2010
Nonnegative matrix factorization (NMF) and nonnegative least squares regression (NNLS regression) are widely used in the physical sciences; this thesis explores the often-overlooked origins of NMF in the psychometrics literature.
Lorenz, Florian M.
core