Results 101 to 110 of about 349,334 (290)

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

open access: yesAdvanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva   +28 more
wiley   +1 more source

Long‐Term Elevated CO2 Improves Soil Health and Rice Yields in Paddy Fields

open access: yesAdvanced Science, EarlyView.
Combining the two longest‐running rice free‐air CO2 enrichment experiments with a global data synthesis, this study demonstrates that long‐term elevated CO2 consistently enhances soil health. In rice paddies, this improvement sustains the CO2 fertilization effect over decades.
Fan Jiang   +22 more
wiley   +1 more source

THE RELATIONSHIP BETWEEN FAMILY SUPPORT AND SOCIAL SUPPORT WITH DIET ADHERENCE OF HYPERTENSIVE PATIENTS

open access: yesJournal of Vocational Nursing
Introduction: Hypertension is an escalating global health issue, with diet playing a critical role in its management by limiting salt and saturated fat intake while increasing the consumption of fruits, vegetables, and fiber.
Hesti Norma Sari   +3 more
doaj   +1 more source

Nonparametric methods [PDF]

open access: yesAmerican Journal of Orthodontics and Dentofacial Orthopedics, 2015
openaire   +2 more sources

NFS1 Regulates IDH2 to Attenuate Abdominal Aortic Aneurysms via Interacting With SP2

open access: yesAdvanced Science, EarlyView.
The loss of NFS1 leads to its reduced binding with the transcription factor SP2, resulting in decreased expression of the downstream gene Idh2. This causes a shift in energy supply toward glycolysis in VSMCs, ultimately contributing to the occurrence and progression of AAA.
Luzheng Zhang   +9 more
wiley   +1 more source

Nonparametric Survival Analysis

open access: yesStatistical Science, 2004
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

METTL1‐Mediated M7G tRNA Modification Promotes Residual Liver Regeneration After Hepatectomy via Translational Control

open access: yesAdvanced Science, EarlyView.
METTL1 and its mediated m7G tRNA modification are significantly up‐regulated after partial hepatectomy (PHx). Overexpression of METTL1 improves the efficiency of liver regeneration after PHx, increases the proliferation of hepatocytes, and accelerates the recovery of liver function.
Manling Huang   +18 more
wiley   +1 more source

Prediction and Monitoring Method for Breast Cancer: A Case Study for Data from the University Hospital Centre of Coimbra

open access: yesCancer Management and Research, 2020
Jin Yue, 1, 2,* Na Zhao, 3,* Liu Liu 1 1School of Mathematics and VC & VR Key Laboratory of Sichuan Province, Sichuan Normal University, Chengdu, People’s Republic of China; 2School of Mathematics, Sichuan University of Arts and Science ...
Yue J, Zhao N, Liu L
doaj  

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

open access: yesAdvanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang   +9 more
wiley   +1 more source

Nonparametric statistical testing of EEG- and MEG-data

open access: yesJournal of Neuroscience Methods, 2007
E. Maris, R. Oostenveld
semanticscholar   +1 more source

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