Results 121 to 130 of about 369,804 (310)
Advanced Science, EarlyView.This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo +17 more
wiley +1 more source
Bandwidth Selection in Nonparametric Kernel Testing [PDF]
We propose a sound approach to bandwidth selection in nonparametric kernel testing. The main idea is to find an Edgeworth expansion of the asymptotic distribution of the test concerned.
Jiti Gao, Irene Gijbels
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Journal of Vocational NursingIntroduction: Hypertension is an escalating global health issue, with diet playing a critical role in its management by limiting salt and saturated fat intake while increasing the consumption of fruits, vegetables, and fiber.
Hesti Norma Sari +3 more
doaj +1 more source
Advanced Science, EarlyView.RGS16 competitively interferes with the YTHDF3–PAN3 complex to prevent CXCL1 mRNA decay during hepatic ischemia‐reperfusion injury. Stabilized CXCL1 strengthens hepatocyte injury, neutrophil recruitment, and NET‐associated inflammation, uncovering how stress‐induced RGS16 converts post‐transcriptional regulation into immune‐mediated liver damage ...
Xinglong Li +16 more
wiley +1 more source
Nonparametric tests of conditional treatment effects [PDF]
We develop a general class of nonparametric tests for treatment effects conditional on covariates. We consider a wide spectrum of null and alternative hypotheses regarding conditional treatment effects, including (i) the null hypothesis of the ...
Sokbae 'Simon' Lee, Yoon-Jae Whang
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Advanced Science, EarlyView.The Gαi1/3 protein is a crucial connecting protein closely related to the signal transduction process of bone formation‐related cytokines such as BMP2. Gαi1/3 mediates downstream signaling pathways such as Smads and MAPK by binding to adaptor proteins like Gab1, thereby promoting the osteogenic effect of BMSCs.
Huajian Shan +10 more
wiley +1 more source
Nonparametric confidence bands in deconvolution density estimation [PDF]
Uniform confidence bands for densities f via nonparametric kernel estimates were first constructed by Bickel and Rosenblatt [Ann. Statist. 1, 1071.1095].
Bissantz, Nicolai +3 more
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Cancer Management and Research, 2020 Jin Yue, 1, 2,* Na Zhao, 3,* Liu Liu 1 1School of Mathematics and VC & VR Key Laboratory of Sichuan Province, Sichuan Normal University, Chengdu, People’s Republic of China; 2School of Mathematics, Sichuan University of Arts and Science ...
Yue J, Zhao N, Liu L
doaj
A Comparison of Parametric, Semi-nonparametric, Adaptive and Nonparametric Cointegration Tests [PDF]
, 1998 This paper provides an extensive Monte-Carlo comparison of severalcontemporary cointegration tests. Apart from the familiar Gaussian basedtests of Johansen, we also consider tests based on non-Gaussianquasi-likelihoods. Moreover, we compare the performance of these parametrictests with tests that estimate the score function from the data using ...
Boswijk, H.P., Lucas, A., Taylor, N.
openaire +6 more sources