Results 171 to 180 of about 19,319 (259)

Nonparametric estimation of density profiles

open access: yesThe Astronomical Journal, 1994
David Merritt, Benoit Tremblay
openaire   +1 more source

Optimal subsampling for regression with mixed‐type predictors

open access: yesCanadian Journal of Statistics, EarlyView.
Abstract Subsampling has emerged as an appealing strategy to mitigate the computational and storage challenges imposed by large datasets. Recent subsampling techniques have shown notable computational gains for data dominated by numerical predictors. However, real‐world datasets frequently contain both numerical and categorical predictors.
Jiaqing Zhu, Lin Wang, Fasheng Sun
wiley   +1 more source

Large parameter asymptotic analysis for homogeneous normalized random measures with independent increments

open access: yesCanadian Journal of Statistics, EarlyView.
Abstract Homogeneous normalized random measures with independent increments represent a broad class of Bayesian nonparametric priors and thus are widely used. In this article, we obtain the strong law of large numbers, the central limit theorem (CLT), and the functional central limit theorem (fCLT) of such measures when the concentration parameter a ...
Junxi Zhang, Shui Feng, Yaozhong Hu
wiley   +1 more source

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor   +12 more
wiley   +1 more source

Effects of Trimethoprim on Three Previously Proposed Putative Biomarkers for OCT2/MATE‐Mediated Renal Drug‐Drug Interactions in Healthy Volunteers

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Regulatory agencies request the assessment of the potential of new drugs to cause transporter‐mediated drug‐drug interactions (DDI). This assessment can be improved by integrating endogenous biomarkers during drug development. Regarding the renal excretion of drugs such as metformin, the organic cation transporter (OCT) 2 and multidrug and toxin ...
Jana Picurová   +5 more
wiley   +1 more source

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