Results 131 to 140 of about 332,602 (334)

Pathogenic Role of FGFR3 Autoantibodies in Small Fiber Neuropathy

open access: yesAdvanced Science, EarlyView.
Autoantibodies against fibroblast growth factor receptor 3 (FGFR3) are identified as pathogenic drivers of pain in small fiber neuropathy. By binding to sensory neurons in dorsal root ganglia, FGFR3 autoantibodies activate MAPK signaling and induce hyperexcitability and mechanical hypersensitivity, establishing FGFR3 autoantibodies as a therapeutic ...
Lyuba Y. Salih   +12 more
wiley   +1 more source

One- and two-sample nonparametric tests for the signal-to-noise ratio based on record statistics

open access: yes, 2015
A new family of nonparametric statistics, the r-statistics, is introduced. It consists of counting the number of records of the cumulative sum of the sample.
Challet, Damien
core   +1 more source

Hierarchical Summary Statistics Encoding Across Primary Visual and Posterior Parietal Cortices

open access: yesAdvanced Science, EarlyView.
This study shows that mouse V1 simultaneously encodes the ensemble mean and variance of motion, providing a robust summary‐statistic representation that persists despite single‐neuron variability. These signals propagate to PPC, where they are transformed into abstract category representations during decision making.
Young‐Beom Lee   +4 more
wiley   +1 more source

Bootstrapped Tests for Epistemic Fuzzy Data

open access: yesInternational Journal of Applied Mathematics and Computer Science
Epistemic bootstrap is a resampling algorithm that generates bootstrap real-valued samples based on some epistemic fuzzy data input. We apply this method as a universal basis for various statistical tests which can be then directly used for fuzzy random ...
Grzegorzewski Przemysław   +1 more
doaj   +1 more source

UBE2T‐Driven p53 Degradation Rewires Glycolysis to Orchestrate Lactylation‐Mediated CAFs Activation and ECM Deposition in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
This study integrates multi‐omics to reveal the critical role of UBE2T in driving malignancy and stromal co‐evolution in PDAC. UBE2T potentiates glycolysis by regulating p53 degradation via a positive feedback loop, thereby promoting histone H3 lysine 18 lactylation in CAFs and stromal deposition. The UBE2T inhibitor PGG represents a potential strategy
Yong Ma   +16 more
wiley   +1 more source

O monge, o executivo e o estudante ludibriado: uma análise empírica sobre leitura eficaz entre alunos de administração

open access: yesCadernos EBAPE.BR
Os cursos de graduação em administração reúnem o maior contingente de estudantes universitários em todo o sistema superior de ensino no Brasil. Por outro lado, desde o surgimento das primeiras escolas, o processo de formação dos futuros gestores e ...
José Luis Felicio Carvalho   +2 more
doaj   +1 more source

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