Results 71 to 80 of about 152,836 (291)

Expanding Genetic Code to Generate Human Brain Organoids with Both Vasculature and Microglia‐Like Cells

Advanced Science, EarlyView.
Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin, Yaqing Wang, Hu Du, Yuxin Qin, Haoyu Zhang, Peng Wang, Lin Wei, Jianhua Qin   +7 more
wiley   +1 more source

Necessary Nonsense: Aesthetics, History, Neurology, Psychology

, 2018
Nonsense: usage and uses -- Metaphor and nonsense -- The baroque: nonsense in prospect and retrospect -- Salutary nonsense: Keats, Kant, and Madame de Staël; or inspiration vs.
Massey, Irving
core   +1 more source

TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton

Advanced Science, EarlyView.
Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne, Aikta Sharma, Scott Dillon, Jacob Keen, Soher N. Jayash, Natalie Crump, Lucinda A.E. Evans, Maya Karmali, Worachet Promruk, Claire E. Clarkin, Sonoko Narisawa, Louise Stephen, Brian L. Foster, José Luis Millán, Colin Farquharson, Katherine A. Staines   +15 more
wiley   +1 more source

The Nascent State

Philosophies
I suggest here ecologies of the nascent state, posing the following general questions: what is this state and what is it to live, to fabricate modes of life, in its immanence?
Filipe Ferreira
doaj   +1 more source

‘NONSENSE’ IN COMIC SCHOLIA

, 2017
In 1968 E.K. Borthwick, with a brilliant conjecture, cleared up a passage from Aristophanes’Peacethat had been considered ‘nonsense’ since antiquity. ‘Bell goldfinch’ (κώδων ἀκαλανθίς) the line seemed to be saying: a jumbled idea at best, gibberish at ...
Stephen E. Kidd
core   +1 more source

CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome

Advanced Science, EarlyView.
By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen, Zhiquan Liu, Wenmin Wang, Qing Wang, Tia J. Kowal, Fan Zhang, Grzegorz Walkiewicz, Faruk Hossen, Herbert M. Lachman, Jinqiong Zhou, Yiting Wang, Yang Sun   +11 more
wiley   +1 more source

Higher forms of nonsense

European Review, 2000
Research councils are under pressure and some are responding pro-actively. This has implications for their functioning as ‘aggregation machines’ taking in proposals and churning out judgements and decisions. Five scenarios of possible futures for research councils in the world of strategic science are laid out, with ...
openaire   +3 more sources

Transposable Element Dynamics Drive the Genomic Evolution and Phenotypic Diversification of Allotetraploid Common Carp

Advanced Science, EarlyView.
By integrating 516 whole‐genome resequencing datasets and 236 transcriptomes of allotetraploid common carp, this study establishes the first population‐scale atlas of transposable element (TE) variation in teleost species. TE bursts, relaxed purifying selection, and lineage‐specific loss of ancient insertions shape genome evolution and phenotypic ...
Shuimu Hu, Zhou Jiang, Lin Chen, Gowena Ling Yi Goh, Weijing Li, Qian He, Xintong Chen, Rui Li, Yuxuan Liu, Ning Li, Tao Zhou, Peng Xu   +11 more
wiley   +1 more source

Humorous TV ads and the 3WD: Evidence for generalizability of humour appreciation across media?

The European Journal of Humour Research, 2017
Individuals differ in their appreciation of jokes and cartoons with respect to the structure of the humorous material (e.g., whether the jokes and cartoons are can be categorised in terms of incongruity-resolution or in terms of nonsense), as well as ...
Jennifer Hofmann, Willibald Friedrich Ruch   +1 more
doaj   +1 more source

Wittgenstein and the Nonsense Predicament [PDF]

, 2016
A single philosophical problem is developed, which will be called the nonsense predicament. The predicament arises because an argument from nonsense—which is an argument that aims to establish that some, or all, philosophical sentences are nonsense ...
Wald, Conrad
core