Results 251 to 260 of about 62,957 (275)

Nonsense suppression in aminoacyl-t-RNA limited cells

Molecular and General Genetics MGG, 1982
A number of nonsense alleles of lacZ exhibit phenotypic suppression (as much as a sixteen-fold increase in leakiness) during partial limitation for certain aminoacyl-tRNA species in relA mutant cells. Each responsive allele has its individual pattern of response to limitation for one or more amino acids or aminoacyl-tRNA's.
J, Gallant, H, Erlich, R, Weiss, L, Palmer, L, Nyari   +4 more
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Nonsense suppression context effects in Escherichia coli bacteriophage T4

Molecular and General Genetics MGG, 1987
Nonsense suppression by supE44 has been examined in a collection of 14 T4 gene 22 and gene 23 UAG mutants, for which the precise gene location is known. In concordance with previous studies, UAG followed by a pyrimidine was inefficiently suppressed. However, among positions with similar 3' nucleotides, there was considerable variation in suppression ...
P, Edelmann, R, Martin, J, Gallant
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mTOR pathway inhibition stimulates pharmacologically induced nonsense suppression

2022
ABSTRACTA large number of human genetic diseases result from premature termination codons (PTCs) caused by splicing defects, insertions, deletions or point mutations also termed nonsense mutations. Nonsense mutations are the source of various genetic diseases, ranging from rare neuro-metabolic disorders to relatively common inheritable cancer syndromes
Amnon Wittenstein, Michal Caspi, Ido Rippin, Orna Elroy-Stein, Hagit Eldar-Finkelmn, Sven Thoms, Rina Rosin-Arbesfeld   +6 more
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Gene selective suppression of nonsense termination using antisense agents

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2005
An estimated one third of all inherited genetic disorders and many forms of cancer are caused by premature (nonsense) termination codons. Aminoglycoside antibiotics are candidate drugs for a large number of such genetic diseases; however, aminoglycosides are toxic, lack specificity and show low efficacy in this application.
Agné, Kulyté, Rikard, Dryselius, Jenny, Karlsson, Liam, Good   +3 more
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Codon context effects on nonsense suppression in human cells

Biochemical Society Transactions, 1993
Carter, P. W., Hartkus, J. M. and Calvo, J. M. (1986) Proc.Natl.Acad.Sci. U.S.A.83,8127-8131 Gabain, A. v., Helasco, J. G.. Schottel, J. I,., Chang, A. C. Y. and Cohen. S. N. (1983) Proc. Natl. Acad. Sci. [J.S.A. 80, 653-657 Petersen, C. (1987) MGG Mol. Gen. Genet. 209, 179187 Spaniard. K. A., Chen, K., Walker, J. K. and van Lhin, J.
R, Martin, M K, Phillips-Jones, F J, Watson, L S, Hill   +3 more
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Suppression of the nonsense mutation in homozygous β0 thalassaemia

Nature, 1979
The common form of beta thalassaemia associated with elevated haemoglobin A2 levels can be broadly classified as beta + or beta 0 type according to the presence or absence of beta-globin chain synthesis in the homozygous state. The molecular pathology of each type is heterogeneous.
J C, Chang, G F, Temple, R F, Trecartin, Y W, Kan   +3 more
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Ochre mutants, a new class of suppressible nonsense mutants

Journal of Molecular Biology, 1965
Suppressors of a strongly polar mutant of the lac gene in Escherichia coli also suppress mutants of the rII genes of bacteriophage T4. Included amongst this set are some amber mutants, but there are also many other mutants which are not suppressed by amber suppressors. These mutants are denned as ochre mutants, and the suppressors as ochre suppressors.
S. BRENNER, J.R. BECKWITH
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Suppression of nonsense mutations by small, cyclic peptides [PDF]

ABSTRACT Premature termination codons in mRNAs result from nonsense mutations and hinder the translation of full-length, functional proteins. Nonsense mutations cause numerous serious genetic diseases, including cystic fibrosis and Duchenne muscular dystrophy.
Nanna Birkmose, Saleem Y. Bhat, Arpan Bhattacharya, Paul R. Hansen, Thomas G. Andersen, Sophia Hunter, Emilie T. Larsen, Yale E. Goldman, Barry S. Cooperman, Charlotte R. Knudsen   +9 more
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Effects of surrounding sequence on the suppression of nonsense codons

Journal of Molecular Biology, 1983
Using a lacI-Z fusion system, we have determined the efficiency of suppression of nonsense codons in the I gene of Escherichia coli by assaying beta-galactosidase activity. We examined the efficiency of four amber suppressors acting on 42 different amber (UAG) codons at known positions in the I gene, and the efficiency of a UAG suppressor at 14 ...
MILLER J. H, ALBERTINI, ALESSANDRA
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Suppressing Nonsense for Gene Therapy

Human Gene Therapy, 2022
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