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Retracted: Expression of p-Akt and COX-2 in Gastric Adenocarcinomas and Adenovirus Mediated Akt1 and COX-2 ShRNA Suppresses SGC-7901 Gastric Adenocarcinoma and U251 Glioma Cell <i>Growth In Vitro</i> and <i>In Vivo</i>. [PDF]

Technol Cancer Res Treat
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Phenotypic suppression of nonsense mutants in yeast by aminoglycoside antibiotics

Nature, 1979
STREPTOMYCIN, an aminoglycoside antibiotic, can reverse the mutant phenotypes of many nonsense and missense mutations in Escherichia coli and in bacteriophage T4. This phenomenon has been called phenotypic suppression, since the mutant phenotype returns after removal of the drug1.
E, Palmer, J M, Wilhelm, F, Sherman
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Nonsense-missense suppression in yeast

Molecular and General Genetics MGG, 1971
A dominant suppressor has been discovered which suppresses polarity type mutations, noncomplementing ones and those belonging to short nonpolar complementation groups at the ad2 locus of S. cerevisiae. The suppressor translates two types of nonsense previously established at ad2.
B V, Simarov, L N, Mironova, S G, Inge-Vechtomov   +2 more
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Nonsense suppression in mammalian cells

Biochimie, 1996
Mammalian cells contain suppressor tRNAs that can translate nonsense codons such as UAG and UGA localized at a specific site of natural mRNAs. For translation of these nonsense codons, a specific secondary or tertiary structure of mRNAs located in the region surrounding the translatable nonsense codon is required.
Y, Kuchino, T, Muramatsu
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Nonsense suppression in Dictyostelium discoideum

Developmental Genetics, 1990
AbstractWe describe the generation of Dictyostelium discoideum cell lines that carry different suppressor †RNA genes. These genes were constructed by primer‐directed mutagenesis changing a †RNATrp(CCA) gene from D. discoideum to a †RNATrp(amber) gene and changing a †RNAGlu(UUC) gene from D.
T, Dingermann, N, Reindl, T, Brechner, H, Werner, K, Nerke   +4 more
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How stop codon pseudouridylation induces nonsense suppression

Computational and Theoretical Chemistry, 2021
Abstract Nonsense mutation can be an inherited disorder or caused by genetic mutation under certain conditions such as stress or exposure. Nonsense suppression, can have a broad potential as a therapeutic approach to nonsense mutation. Pseudouridine is proposed to result in nonsense suppression if induced in one of the three nonsense codons, Amber ...
Hadieh Monajemi, Sharifuddin M. Zain
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Genetic studies on temperature sensitive nonsense suppression

Molecular and General Genetics MGG, 1970
Temperature sensitive suppression of nonsense mutations has been obtained, in E. coli, by inducing a mutation in the suppressor gene su-4, a structural gene for a tyrosine tRNA. In this mutant while no suppression is detectable at 42°C it is always present at lower temperatures.
E, Gallucci, G, Pacchetti, S, Zangrossi
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Nonsense Suppression Approaches in Treating Hemophilia

Blood, 2008
Abstract Genetic diseases can result from nonsense mutations that cause premature translation termination. Nonsense mutations account for ~10–15% of all cases of hemophilia A and B and this population may benefit from small molecule-induced readthrough of nonsense codons.
Katherine A. High, Marla Weetall, Ellen Welch, Josephine Sheedy, Nicole Hasbrouck, Stephan Kadauke, Harre Downey, Fayaz Khazi, Paris Margaritis, Yi-Lin Liu   +9 more
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Nonsense suppression in Archaea

Trends in Biochemical Sciences, 2001
The Archaea are an incredibly diverse kingdom of microbes that can thrive under a huge range of chemical and physical conditions. Among the many unusual aspects of archaeal cellular and molecular biology, their ability to grow on a variety of exotic compounds holds a particular fascination for biochemists.
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Aminoglycoside suppression of nonsense mutations in severe hemophilia

Blood, 2005
AbstractAminoglycoside antibiotics exhibit their bactericidal effect by interfering with normal ribosomal activity. In this pilot study, we have evaluated the effect of the aminoglycoside antibiotic gentamicin on the factor VIII (FVIII) and IX levels of severe hemophiliacs with known nonsense mutations.
Paula D, James, Sanj, Raut, Georges E, Rivard, Man-Chiu, Poon, Margaret, Warner, Susan, McKenna, Jayne, Leggo, David, Lillicrap   +7 more
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