Results 221 to 230 of about 62,957 (275)

The Affirmative Biopolitics of Anxiety in China: Ambivalence, Marginalisation and Resistance Under the ‘Double Reduction’ Policy

Transactions of the Institute of British Geographers, Volume 51, Issue 2, June 2026.
ABSTRACT The ‘affirmative turn’ in Geography has generally been read positively for promoting care‐full urban governance, repairing inter‐group relations and enhancing socio‐spatial justice, while largely neglecting the biopolitics, marginalisation and resistance embedded therein.
Qiong He, Shenjing He
wiley   +1 more source

SIRT1 Prevents Ferroptosis in Corneal Epithelial Cells by Enhancing HIF1α Protein Stability in Dry Eye Disease

Advanced Science, Volume 13, Issue 26, 8 May 2026.
Hyperosmotic stress drives ferroptosis in corneal epithelium via SIRT1 downregulation. This work demonstrates that SIRT1 activation stabilizes HIF1α, which transcriptionally upregulates GPX4 to inhibit lipid peroxidation and cell death. The identified SIRT1/HIF1α/GPX4 axis reveals a novel defense mechanism and potential therapy for dry eye disease ...
Lili Lian, Zhenmin Le, Xuanqiao Ye, Zimo Wang, Jiuxiao Li, Chenyu Dong, Yetao Shen, Jiazheng Li, Yueping Ren, Xiaoyin Ma, Wei Chen, Qinxiang Zheng   +11 more
wiley   +1 more source

Deciphering the Impact of RAC1‐SPTAN1 in ARPKD Cystogenesis Using Multifaceted Models

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Distal/connecting tubules expressing SLC8A1 have been suggested as a potential origin of ARPKD cysts. SPTAN1 has been identified as a key molecule in ARPKD cyst formation. Restoring SPTAN1 in PKHD1−/− organoids reduced cyst formation, normalized calcium levels, and decreased RAC1/c‐FOS expression, highlighting SPTAN1's role in ARPKD and the potential ...
Shohei Kuraoka, Yuhei Higashi, Suguru Saito, Solmaz Pourgonabadi, Honami Honjoh, Sho Ishigaki, Peter C. Harris, Lisa M. Satlin, Michifumi Yamashita, Ryuji Morizane   +9 more
wiley   +1 more source

Beyond readthrough: ataluren restores mitochondrial function and reduces oxidative stress in FANCA-mutated cells via mTOR-DRP1 modulation. [PDF]

Cell Death Discov
Balbi M, Guidi E, Hristodor AM, Corsolini F, Cossu V, Bottega R, Serra M, Pestarino S, Bartolucci M, Cipolli M, Regis S, Bezzerri V, Cappelli E, Ravera S.   +13 more
europepmc   +1 more source

Model‐Inversion‐Resistant Physical Unclonable Neural Network Using Vertical NAND Flash Memory

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Schematic and key features of the proposed forward‐forward physical unclonable neural network (FF‐PUNN), incorporating a concealable physical unclonable function (PUF) layer and forward‐forward (FF) learning. ABSTRACT The growing use of neural networks in privacy‐sensitive applications necessitates architectures that inherently protect both data and ...
Sung‐Ho Park, Ryun‐Han Koo, Jonghyun Ko, Jiseong Im, Yeongheon Yang, Mingyun Oh, Dongbeen Shin, Gyuweon Jung, Jong‐Ho Lee   +8 more
wiley   +1 more source

MAP3K1/MAP2K4 mutations drive breast cancer progression by compensating for TP53 loss through inactivation of the JNK2-p53-FOSL1 axis. [PDF]

Breast Cancer Res
Hu S, Ji A, Wang M, Li X, Sun L, Gao R, Zhang Y.   +6 more
europepmc   +1 more source

Carbon Dot Self‐Assembly: Bottom‐Up Fabrication, Morphological Evolution, Luminescence Regulation, and Advanced Applications

Aggregate, Volume 7, Issue 5, May 2026.
The self‐assembly of carbon dots, which enables precise control over their macroscopic architectures and collective properties, profoundly enhances their functionality. This review systematically summarizes the field through four key aspects—morphology control, luminescence modulation, assembly mechanisms, and advanced applications—and thereby offers a
Kai Chen, Zhi‐Min Zhao, Zhi‐Hua Liu, Li Xu, Junbo Gong, Bing‐Zhi Li   +5 more
wiley   +1 more source

Single Cell RNA Transcriptomics of Mantle Cell Lymphoma Reveals the Presence of Treatment‐Resistant Subclones at the Time of Diagnosis

American Journal of Hematology, Volume 101, Issue 5, Page 1025-1035, May 2026.
ABSTRACT Mantle cell lymphoma (MCL) is a B‐cell malignancy with a chronically relapsing clinical course and pronounced genetic heterogeneity. To investigate the clonal dynamics underlying early disease relapse, we performed single‐cell RNA sequencing of paired tumor samples collected at diagnosis and at first relapse. Inference of copy number variants (
Dmitry Manakov, Magdalena Klanova, Michal Kolar, Robert Ivanek, Florian Geier, Julien Roux, Tomas Zikmund, Lucie Winkowska, Eva Kriegova, Jirina Manakova, Liliana Tuskova, Silvia Spanikova, Alexandra Scasna, Marek Trneny, Pavel Klener   +14 more
wiley   +1 more source

Nonsense-mediated mRNA decay: a key regulatory system engaged in cancer. [PDF]

Cell Commun Signal
Pan H, Wu X, Hu B, Xiong H, Luo Y, Zhou JK.   +5 more
europepmc   +1 more source

Moderating Role of Psychological Flexibility in the Relationship Between Intolerance of Uncertainty and Perceived Stress Among Women Undergoing in Vitro Fertilization Treatment

Brain and Behavior, Volume 16, Issue 5, May 2026.
Intolerance of uncertainty (IU) and psychological inflexibility (PI) positively predict perceived stress (PS) among women undergoing IVF treatment. Psychological flexibility (PF) moderates this relationship, reducing the effect of IU on PS. Women with higher PF experience lower PS despite uncertainty, highlighting the protective role of PF in stressful
Fatemeh karimzadeh, Abbas Abdollahi, Soolmaz Dehghanidowlatabadi   +2 more
wiley   +1 more source