Results 201 to 210 of about 20,553 (236)

Nonsense-missense suppression in yeast

Molecular and General Genetics MGG, 1971
A dominant suppressor has been discovered which suppresses polarity type mutations, noncomplementing ones and those belonging to short nonpolar complementation groups at the ad2 locus of S. cerevisiae. The suppressor translates two types of nonsense previously established at ad2.
B V, Simarov, L N, Mironova, S G, Inge-Vechtomov   +2 more
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Nonsense suppression in mammalian cells

Biochimie, 1996
Mammalian cells contain suppressor tRNAs that can translate nonsense codons such as UAG and UGA localized at a specific site of natural mRNAs. For translation of these nonsense codons, a specific secondary or tertiary structure of mRNAs located in the region surrounding the translatable nonsense codon is required.
Y, Kuchino, T, Muramatsu
openaire   +2 more sources

Nonsense suppression in Dictyostelium discoideum

Developmental Genetics, 1990
AbstractWe describe the generation of Dictyostelium discoideum cell lines that carry different suppressor †RNA genes. These genes were constructed by primer‐directed mutagenesis changing a †RNATrp(CCA) gene from D. discoideum to a †RNATrp(amber) gene and changing a †RNAGlu(UUC) gene from D.
T, Dingermann, N, Reindl, T, Brechner, H, Werner, K, Nerke   +4 more
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Aminoglycoside suppression of nonsense mutations in severe hemophilia

Blood, 2005
AbstractAminoglycoside antibiotics exhibit their bactericidal effect by interfering with normal ribosomal activity. In this pilot study, we have evaluated the effect of the aminoglycoside antibiotic gentamicin on the factor VIII (FVIII) and IX levels of severe hemophiliacs with known nonsense mutations.
Paula D, James, Sanj, Raut, Georges E, Rivard, Man-Chiu, Poon, Margaret, Warner, Susan, McKenna, Jayne, Leggo, David, Lillicrap   +7 more
openaire   +2 more sources

The isolation of a suppressible nonsense mutant in mammalian cells

Cell, 1977
An HGPRT- cell line derived from mouse L cells has been shown to have the following properties: it is CRM+; the defective HGPRT molecules are altered in the carboxyterminal peptide; the mutant cells regain HGPRT activity when ochre-suppressor tRNA is microinjected into them, but not when amber-suppressor or wild-type tRNAs are injected.
M R, Capecchi, R A, Haar, N E, Capecchi, M M, Sveda   +3 more
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Nonsense suppression in Archaea

Trends in Biochemical Sciences, 2001
The Archaea are an incredibly diverse kingdom of microbes that can thrive under a huge range of chemical and physical conditions. Among the many unusual aspects of archaeal cellular and molecular biology, their ability to grow on a variety of exotic compounds holds a particular fascination for biochemists.
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The requirement of nonsense suppression for the development of several phages

Molecular and General Genetics MGG, 1979
A spontaneous streptomycin-resistant Escherichia coli mutant which is temperature-sensitive for suppression of a nonsense codon was studied for its ability to propagate phages T2, T4D, T5, phi K, f2, MS2, R17, Q beta, lambda as well as filamentous phages fl, fd and M13.
H, Engelberg-Kulka, L, Dekel, M, Israeli-Reches, M, Belfort   +3 more
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Effects of surrounding sequence on the suppression of nonsense codons

Journal of Molecular Biology, 1983
Using a lacI-Z fusion system, we have determined the efficiency of suppression of nonsense codons in the I gene of Escherichia coli by assaying beta-galactosidase activity. We examined the efficiency of four amber suppressors acting on 42 different amber (UAG) codons at known positions in the I gene, and the efficiency of a UAG suppressor at 14 ...
MILLER J. H, ALBERTINI, ALESSANDRA
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Genetic studies on temperature sensitive nonsense suppression

Molecular and General Genetics MGG, 1970
Temperature sensitive suppression of nonsense mutations has been obtained, in E. coli, by inducing a mutation in the suppressor gene su-4, a structural gene for a tyrosine tRNA. In this mutant while no suppression is detectable at 42°C it is always present at lower temperatures.
E, Gallucci, G, Pacchetti, S, Zangrossi
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Suppression of the nonsense mutation in homozygous β0 thalassaemia

Nature, 1979
The common form of beta thalassaemia associated with elevated haemoglobin A2 levels can be broadly classified as beta + or beta 0 type according to the presence or absence of beta-globin chain synthesis in the homozygous state. The molecular pathology of each type is heterogeneous.
J C, Chang, G F, Temple, R F, Trecartin, Y W, Kan   +3 more
openaire   +2 more sources