Results 211 to 220 of about 20,553 (236)

Nonsense Suppression Approaches in Treating Hemophilia

Blood, 2008
Abstract Genetic diseases can result from nonsense mutations that cause premature translation termination. Nonsense mutations account for ~10–15% of all cases of hemophilia A and B and this population may benefit from small molecule-induced readthrough of nonsense codons.
Katherine A. High, Marla Weetall, Ellen Welch, Josephine Sheedy, Nicole Hasbrouck, Stephan Kadauke, Harre Downey, Fayaz Khazi, Paris Margaritis, Yi-Lin Liu   +9 more
openaire   +1 more source

Suppression in vitro: Identification of a Serine-sRNA as a "Nonsense" Suppressor

Science, 1965
In a cell-free system, with RNA from a suppressible mutant of bacteriophage R17 as messenger,. no functional coat protein of the bacteriophage is synthesized unless serine-accepting soluble RNA from the suppressor strain, Escherichia coli S26RIE, is present.
M R, Capecchi, G N, Gussin
openaire   +2 more sources

Nonsense suppression in aminoacyl-t-RNA limited cells

Molecular and General Genetics MGG, 1982
A number of nonsense alleles of lacZ exhibit phenotypic suppression (as much as a sixteen-fold increase in leakiness) during partial limitation for certain aminoacyl-tRNA species in relA mutant cells. Each responsive allele has its individual pattern of response to limitation for one or more amino acids or aminoacyl-tRNA's.
J, Gallant, H, Erlich, R, Weiss, L, Palmer, L, Nyari   +4 more
openaire   +2 more sources

Ochre mutants, a new class of suppressible nonsense mutants

Journal of Molecular Biology, 1965
Suppressors of a strongly polar mutant of the lac gene in Escherichia coli also suppress mutants of the rII genes of bacteriophage T4. Included amongst this set are some amber mutants, but there are also many other mutants which are not suppressed by amber suppressors. These mutants are denned as ochre mutants, and the suppressors as ochre suppressors.
S. BRENNER, J.R. BECKWITH
openaire   +1 more source

Codon context effects on nonsense suppression in human cells

Biochemical Society Transactions, 1993
Carter, P. W., Hartkus, J. M. and Calvo, J. M. (1986) Proc.Natl.Acad.Sci. U.S.A.83,8127-8131 Gabain, A. v., Helasco, J. G.. Schottel, J. I,., Chang, A. C. Y. and Cohen. S. N. (1983) Proc. Natl. Acad. Sci. [J.S.A. 80, 653-657 Petersen, C. (1987) MGG Mol. Gen. Genet. 209, 179187 Spaniard. K. A., Chen, K., Walker, J. K. and van Lhin, J.
R, Martin, M K, Phillips-Jones, F J, Watson, L S, Hill   +3 more
openaire   +2 more sources

Phenotypic suppression of nonsense mutants in yeast by aminoglycoside antibiotics

Nature, 1979
STREPTOMYCIN, an aminoglycoside antibiotic, can reverse the mutant phenotypes of many nonsense and missense mutations in Escherichia coli and in bacteriophage T4. This phenomenon has been called phenotypic suppression, since the mutant phenotype returns after removal of the drug1.
E, Palmer, J M, Wilhelm, F, Sherman
openaire   +2 more sources

Suppression of nonsense mutations by small, cyclic peptides

ABSTRACT Premature termination codons in mRNAs result from nonsense mutations and hinder the translation of full-length, functional proteins. Nonsense mutations cause numerous serious genetic diseases, including cystic fibrosis and Duchenne muscular dystrophy. Several small-molecule drugs have been reported that could
Nanna Birkmose, Saleem Y. Bhat, Arpan Bhattacharya, Paul R. Hansen, Thomas G. Andersen, Sophia Hunter, Emilie T. Larsen, Yale E. Goldman, Barry S. Cooperman, Charlotte R. Knudsen   +9 more
openaire   +2 more sources

Suppressing Nonsense for Gene Therapy

Human Gene Therapy, 2022
openaire   +1 more source

How stop codon pseudouridylation induces nonsense suppression

Computational and Theoretical Chemistry, 2021
Hadieh Monajemi, Sharifuddin M Zain
exaly  

Suppressing Nonsense

Nature, 1969
openaire   +1 more source