Results 291 to 300 of about 160,452 (346)
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Chemistry of the Nonsteroid Hormones
Annual Review of Biochemistry, 1952INTRODUCTION The comp ss of this chapter as proposed by its title is the chemistry of all the nonsteroid hormones. Two years have elapsed since the subject was last reviewed and it is evident that it would be impossible to give adequate treatment, or even mention, to all of the material which has appeared during that time.
C H Li, J I Harris
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Discovery of Nonsteroidal Androgens
Biochemical and Biophysical Research Communications, 1998Nonsteroidal androgens have not been reported. During studies to identify affinity ligands for the androgen receptor in our laboratory, we synthesized several electrophilic nonsteroidal ligands for the androgen receptor and examined their receptor binding affinity and ability to stimulate receptor-mediated transcriptional activation.
Duane D. Miller +4 more
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Science, 1960
2-Acetyl-7-oxo-1, 2, 3, 4, 4a, 4b, 5, 6, 7, 9, 10, 10a-dodecahydrophenanthrene possesses androgenic activity when applied directly to the chick's comb. This action is in addition to the antiandrogenic activity previously reported for this compound. This is the first demonstration of androgenic activity by a compound not possessing the steroid nucleus.
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2-Acetyl-7-oxo-1, 2, 3, 4, 4a, 4b, 5, 6, 7, 9, 10, 10a-dodecahydrophenanthrene possesses androgenic activity when applied directly to the chick's comb. This action is in addition to the antiandrogenic activity previously reported for this compound. This is the first demonstration of androgenic activity by a compound not possessing the steroid nucleus.
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Nonsteroidal antiinflammatory drugs and the stomach
Current Opinion in Gastroenterology, 2002We review papers on nonsteroidal antiinflammatory drugs (NSAID) and the stomach published in the 12 months ending April 2002. During this period, some further developments occurred in the ongoing search for safer antiinflammatory drugs. The highly selective COX-2 inhibitors (COX-2i) have again exhibited some toxicity in animal models of repair, but ...
Gerard J. Mccaffrey +2 more
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Nonsteroidal antagonists of the mineralocorticoid receptor
Current Opinion in Nephrology and Hypertension, 2015The broad clinical use of steroidal mineralocorticoid receptor antagonists (MRAs) is limited by the potential risk of inducing hyperkalemia when given on top of renin-angiotensin system blockade. Drug discovery campaigns have been launched aiming for the identification of nonsteroidal MRAs with an improved safety profile.
Peter Kolkhof
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Nonsteroidal Anti-Inflammatory Drugs
Veterinary Clinics of North America: Equine Practice, 1993NSAIDs' mechanism of action by inhibiting the synthesis of prostanoids accounts for both their therapeutic and toxic effects. They are commonly used in acute and chronic musculoskeletal and soft-tissue conditions. Adverse reactions include gastrointestinal disturbances and hypoproteinemia. Their pharmacologic effect seems to have a longer duration than
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Nonsteroidal antiinflammatory agents
Drugs of Today, 1999Since the synthesis of aspirin in 1897, aspirin-like or nonsteroidal antiinflammatory drugs (NSAIDs) have been the mainstay of therapy for rheumatoid arthritis. Although of diverse chemical structure, these drugs not only exhibit the same antipyretic, analgesic and antiinflammatory therapeutic actions, but they also manifest identical toxic actions on ...
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Nonsteroidal Ecdysone Agonists
2005Nonsteroidal ecdysone agonists are novel compounds that have become attractive candidates not only as pest control agents in agriculture but also as tools for research. Their narrow spectrum of activity makes them relatively safe as pesticides, and their mode of action as ligands for gene expression has found application in gene therapy and inducing ...
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Nonsteroidal Anti-inflammatory Drugs
Archives of Internal Medicine, 1984Over the past decade, many new nonsalicylate, nonsteroidal anti-inflammatory drugs (NSAIDs) have been introduced in the United States. These include fenoprofen, ibuprofen, meclofenamate, naproxen, piroxicam, sulindac, and tolmetin in addition to indomethacin and phenylbutazone, which were previously available.
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