Results 41 to 50 of about 161,622 (300)

Use of a Molecular Signature Response Classifier to Inform Treatment Selection Improves Clinical Disease Activity Among Patients with Rheumatoid Arthritis Initiating a Biologic or Targeted Synthetic Disease‐Modifying Antirheumatic Drug

Arthritis Care &Research, EarlyView.
Objective We assessed the effectiveness of PrismRA to improve clinical outcomes among patients with rheumatoid arthritis (RA) initiating treatment with a biologic or targeted synthetic disease‐modifying antirheumatic drug (b/tsDMARD). Methods PrismRA incorporated 19 gene expression features and four clinical features to assess a patient's likelihood of
Fenglong Xie, Timothy Beukelman, Nicholas P. McCormick, Jeffrey R. Curtis   +3 more
wiley   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

WAYS TO IMPROVE THE EFFICACY AND SAFETY OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS: THE ROLE OF GLYCYRRHIZIC ACID

Актуальные проблемы теоретической и клинической медицины
Relevance. This article presents an analytical review of current approaches aimed at improving the efficacy and safety of nonsteroidal anti-inflammatory drugs, which are widely used in clinical practice for inflammatory and pain syndromes.
Zh. Sh. Azen, T. B. Zhorabek, T. A. Arystanova   +2 more
doaj   +1 more source

COMPARISON OF SELECTIVE AND NON SELECTIVE CYCLO-OXYGENASE 2 INHIBITORS IN EXPERIMENTAL COLITIS EXACERBATION: role of leukotriene B4 and superoxide dismutase

Arquivos de Gastroenterologia, 2014
Context Nonsteroidal anti-inflammatory drugs are considered one of the most important causes of reactivation of inflammatory bowel disease. With regard to selective cyclo-oxygenase 2 inhibitors, the results are controversial in experimental colitis as ...
José Wander BREGANÓ, Décio Sabbatini BARBOSA, Mirian Zebian El KADRI, Maria Aparecida RODRIGUES, Rubens CECCHINI, Isaias DICHI   +5 more
doaj   +1 more source

A rare case of appendicular skeleton localization in a patient with chronic lymphocytic leukemia successfully treated with salvage radiation therapy [PDF]

, 2017
Bone involvements in chronic lymphocytic leukemia (CLL) are considered rare events, and the English-language medical literature describes them only in sporadic case reports. Consequently, robust indications for a rational clinical management are lacking.
Al Sayyad, Said, Arico, Demetrio, Di Cristofano, Claudio, Marchione, Anna Maria, Petrozza, Vincenzo, Porta, Natale, Ronco, Francesca, Russi, Elvio Grazioso, Sceni, Giuseppe, Stelitano, Caterina, Tuscano, Carmelo, Versace, Paolo, Vincelli, Iolanda Donatella   +12 more
core   +1 more source

Facing Facts: Facial Injuries from Stand-up Electric Scooters [PDF]

, 2020
Background Stand-up electric scooters (SES) are a popular public transportation method. Numerous safety concerns have arisen since their recent introduction.
Alwani, Mohamedkazim, Bandali, Elhaam, Jones, Alexander J., Lancaster, Benjamin, Sandelski, Morgan, Shipchandler, Taha, Sim, Michael W., Ting, Jonathan   +7 more
core   +2 more sources

Does Long‐Term Lower Extremity Strength Training in Adults With Knee Osteoarthritis and Varus Alignment Reduce Knee Joint Loading During Gait?

Arthritis Care &Research, EarlyView.
Objective We examined whether 18 months of strength training in individuals with knee varus alignment and medial tibiofemoral osteoarthritis (OA) reduced knee joint loads during walking compared to an attention control group. Methods This study was a secondary analysis of a randomized clinical trial that compared the effects of strength training to a ...
Stephen P. Messier, Matthew N. Vigliotti, Paige E. Rice, Brian Pietrosimone, Shannon L. Mihalko, Edward H. Ip, Richard F. Loeser, David J. Hunter, Ali Guermazi, Ryan Hill, Santiago Saldana, Kim L. Bennell, Paul DeVita   +12 more
wiley   +1 more source

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

Effects of periarticular injection on analgesic effects and NSAID use in total knee arthroplasty and total hip arthroplasty

Clinics
OBJECTIVES: This study examined periarticular multimodal drug injection and the use of nonsteroidal anti-inflammatory drugs for an early analgesic effect after total knee arthroplasty and total hip arthroplasty. Patient satisfaction and benefits from the
Wen-rui Ban, Ery-ang Zhang, Lei-feng Lv, Xiao-qian Dang, Chen Zhang   +4 more
doaj   +1 more source

Clinical Management of Nonsteroidal Anti-inflammatory Drug Hypersensitivity

World Allergy Organization Journal, 2008
Hypersensitivity diseases caused by nonsteroidal anti-inflammatory agents are relatively common in the population. This article summarizes the present understanding on the various allergic and nonallergic clinical pictures produced through ...
Mario Sánchez-Borges, MD
doaj   +1 more source