Results 101 to 110 of about 56,005 (221)

Mapping of transcription termination within the S segment of SFTS phlebovirus facilitated the generation of NSs-deletant viruses [PDF]

, 2017
SFTS phlebovirus (severe fever with thrombocytopenia syndrome virus; SFTSV) is an emerging tick-borne bunyavirus that was first reported in China in 2009. Here we report the generation of a recombinant SFTSV (rHB29NSsKO) that cannot express the viral non-
Brennan, Benjamin, Elliott, Richard M., Rezelj, Veronica V.   +2 more
core   +1 more source

Korat‐Scrub Typhus Score: A Clinical Tool for Predicting Scrub Typhus in Patients With Acute Undifferentiated Febrile Illness

Tropical Medicine &International Health, EarlyView.
ABSTRACT Objective Scrub typhus is a major cause of acute undifferentiated febrile illness (AUFI) in the Asia–Pacific region. Nonspecific presentation, limited diagnostic accuracy and delayed treatment increase morbidity and mortality. This study aimed to develop a simple clinical score for early diagnosis in adults with AUFI. Methods A cross‐sectional
Wilawan Thipmontree, Ekkarat Wongsawat, Saowaluk Silpasakorn, Yupin Suputtamongkol   +3 more
wiley   +1 more source

A single mutation may contribute to accelerated evolution of SARS-CoV-2 toward Omicron

Nature Communications
How SARS-CoV-2 Omicron evolved remains obscure. T492I, an Omicron-specific mutation encountered in SARS-CoV-2 nonstructural protein 4 (NSP4), enhances viral replication and alters nonstructural protein cleavage, inferring potentials to drive evolution ...
Xiaoyuan Lin, Zhou Sha, Chunlin Zhang, Julia M. Adler, Ricardo Martin Vidal, Christine Langner, Beibei Fu, Yan Xiong, Meng Tan, Chen Jiang, Hao Zeng, Xiaokai Zhang, Qian Li, Jingmin Yan, Xiaoxue Lu, Shiwei Wang, Xuhu Mao, Dusan Kunec, Jakob Trimpert, Haibo Wu, Quanming Zou, Zhenglin Zhu   +21 more
doaj   +1 more source

Sporadic Occurrence of Ensitrelvir-Resistant SARS-CoV-2, Japan

Emerging Infectious Diseases
Using the GISAID EpiCoV database, we identified 256 COVID-19 patients in Japan during March 31–December 31, 2023, who had mutations in the SARS-CoV-2 nonstructural protein 5 conferring ensitrelvir resistance.
Akihiro Doi, Masayuki Ota, Masumichi Saito, Shutoku Matsuyama   +3 more
doaj   +1 more source

Robustness of high‐throughput prediction of leaf ecophysiological traits using near infrared spectroscopy and poro‐fluorometry

The Plant Phenome Journal, Volume 9, Issue 1, December 2026.
Abstract Water scarcity is a major threat to crop production and quality. Improving drought tolerance through variety selection requires a deeper understanding of plant ecophysiological responses, but large‐scale phenotyping remains a bottleneck. This study assessed the potential of high‐throughput tools (spectroscopy and poro‐fluorometry) to predict ...
Eva Coindre, Romain Boulord, Laurine Chir, Virgilio Freitas, Maxime Ryckewaert, Thomas Laisné, Virginie Bouckenooghe, Maëlle Lis, Llorenç Cabrera‐Bosquet, Agnès Doligez, Thierry Simonneau, Benoît Pallas, Aude Coupel‐Ledru, Vincent Segura   +13 more
wiley   +1 more source

Expression and function of osteopontin variants in HCV-related liver disease and hepatocellular carcinoma. [PDF]

, 2010
Osteopontin (OPN) is a highly secreted multi-functional sialoprotein that is widely expressed in tissues, blood and urine. It is involved in a number of normal physiological functions, but is also significantly elevated in a number of cancers.
Phillips, Renee Jade
core   +1 more source

The antiviral RNAi response in vector and non-vector cells against orthobunya viruses [PDF]

, 2017
Background: Vector arthropods control arbovirus replication and spread through antiviral innate immune responses including RNA interference (RNAi) pathways. Arbovirus infections have been shown to induce the exogenous small interfering RNA (siRNA) and
Bausch, DG, Blomström, AL, Dietrich, I, Elliott, RM, Kohl, A, McFarlane, M, Schnettler, E, Shi, X, Skelton, JK, Watson, M   +9 more
core   +5 more sources

Impact of Crude Oil Contamination on Green Leafy Vegetables: Nutritional and Health Risk Assessments

Remediation Journal, Volume 36, Issue 2, Spring 2026.
ABSTRACT For decades, crude oil spills have been a serious environmental challenge which have led to the establishment of crude oil remediation intervention values (CRIV) by different national agencies to regulate the release of toxic petroleum hydrocarbons via these spills.
Johnson Oluwaseun Odukoya, Ronnie Lambert, Ruben Sakrabani   +2 more
wiley   +1 more source

Allosteric Regulation of RNA Affinity by Motif V‐VI Coupling in West Nile Virus NS3 Helicase

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 6, Page 1212-1224, June 2026.
ABSTRACT The rise of flaviviral diseases, including West Nile virus (WNV), presents a growing threat to global public health and underscores the urgent need for new therapeutic strategies. The non‐structural protein 3 helicase (NS3h) of the Orthoflavivirus genus, including WNV, is essential for viral replication and a promising antiviral target ...
Priti Roy, Martin McCullagh
wiley   +1 more source

A Framework for Emergency Department–Integrated Hepatitis C Test‐and‐Treat in the United States

Journal of Viral Hepatitis, Volume 33, Issue 6, June 2026.
ABSTRACT Despite the availability of curative, direct‐acting antiviral therapy, hepatitis C virus elimination remains incomplete. Losses across the care cascade continue to limit impact, from initial diagnosis to sustained virologic response. Fewer than 1/3 of individuals ultimately achieve cure. These gaps reflect a delivery system that does not align
Saeed S. Graham
wiley   +1 more source