Results 51 to 60 of about 56,005 (221)

Mapping the Nonstructural Transmembrane Proteins of Severe Acute Respiratory Syndrome Coronavirus 2

Journal of Computational Biology, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the disease coronavirus-19 disease (COVID-19) has wreaked havoc on the health and economy of humanity. In addition, the disease is observed in domestic and wild animals. The disease has impacted directly and indirectly every corner of the planet.
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Chikungunya virus infection disrupts MHC-I antigen presentation via nonstructural protein 2

, 2023
ABSTRACTInfection by chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes severe polyarthralgia and polymyalgia, which can last in some people for months to years. Chronic CHIKV disease signs and symptoms are associated with the persistence of viral nucleic acid and antigen in tissues.
Brian C. Ware, M. Guston Parks, Thomas E. Morrison   +2 more
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Binding of a pyrimidine RNA base-mimic to SARS-CoV-2 nonstructural protein 9 [PDF]

Journal of Biological Chemistry, 2021
The coronaviral nonstructural protein 9 (Nsp9) is essential for viral replication; it is the primary substrate of Nsp12's pseudokinase domain within the viral replication transcription complex, an association that also recruits other components during different stages of RNA reproduction. In the unmodified state, Nsp9 forms an obligate homodimer via an
Dene R. Littler, Biswaranjan Mohanty, Shea A. Lowery, Rhys N. Colson, Benjamin S. Gully, Stanley Perlman, Martin J. Scanlon, Jamie Rossjohn   +7 more
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Immunogenicity evaluation of a DNA vaccine expressing the hepatitis C virus non-structural protein 2 gene in C57BL/6 Mice [PDF]

, 2013
Backgrounds: Most of the hepatitis C virus (HCV) infections elicit poor immune responses and 75% to 85% of cases become chronic; therefore, the development of an effective vaccine against HCV is of paramount importance.
Behnampour, N., Ghaemi, A., Gorzin, A.A., Gorzin, Z., Irani, S., Tabarraei, A.   +5 more
core   +2 more sources

Adeno-Associated Virus Type 2 Nonstructural Protein Rep78 Suppresses Translation in Vitro

Virology, 2000
Adeno-associated virus type 2 nonstructural protein Rep78 [621 amino acids (aa) long] affects the expression of various cellular and viral genes. In this study we examined the effects of Rep78 on expression of the luciferase gene from the human cytomegalovirus immediate-early promoter in HeLa cells and on translation of RNA encoding luciferase in ...
Takeuchi, Takamasa, Kozuka, Takuyou, Nakagawa, Keiichi, Aoki, Yukimasa, Ohtomo, Kuni, Yoshiike, Kunito, Kanda, Tadahito   +6 more
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SARS-CoV-2 Uses Nonstructural Protein 16 To Evade Restriction by IFIT1 and IFIT3

Journal of Virology, 2022
Similar to other coronaviruses, disruption of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) NSP16 function attenuates viral replication in a type I interferon-dependent manner. In vivo , our results show reduced disease and viral replication at late times in the hamster lung ...
Craig Schindewolf, Kumari Lokugamage, Michelle N. Vu, Bryan A. Johnson, Dionna Scharton, Jessica A. Plante, Birte Kalveram, Patricia A. Crocquet-Valdes, Stephanea Sotcheff, Elizabeth Jaworski, Rojelio E. Alvarado, Kari Debbink, Matthew D. Daugherty, Scott C. Weaver, Andrew L. Routh, David H. Walker, Kenneth S. Plante, Vineet D. Menachery   +17 more
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Optimizing peptide inhibitors of SARS-Cov-2 nsp10/nsp16 methyltransferase predicted through molecular simulation and machine learning

Informatics in Medicine Unlocked, 2022
Coronaviruses, including the recent pandemic strain SARS-Cov-2, use a multifunctional 2′-O-methyltransferase (2′-O-MTase) to restrict the host defense mechanism and to methylate RNA.
John R. Hamre, III, M. Saleet Jafri
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Novel Mutation of SARS-CoV-2, Vietnam, July 2020

Emerging Infectious Diseases, 2021
A cluster of severe acute respiratory syndrome coronavirus 2 infections in Danang, Vietnam, began July 25, 2020, and resulted in 551 confirmed cases and 35 deaths as of February 2021.
Hoang Vu Mai Phuong, Trinh Son Tung, Ung Thi Hong Trang, Nguyen Le Khanh Hang, Nguyen Vu Son, Pham thi Hien, Le thi Thanh, Vuong Duc Cuong, Ton That Thanh, Nguyen thi Thanh Nhan, Tran Nhu Duong, Ngu Duy Nghia, Tran Anh Tu, Marc Choisy, Maia A. Rabaa, H. Rogier van Doorn, Dang Duc Anh, Le Quynh Mai   +17 more
doaj   +1 more source

Schmallenberg virus pathogenesis, tropism and interaction with the innate immune system of the host [PDF]

, 2013
Schmallenberg virus (SBV) is an emerging orthobunyavirus of ruminants associated with outbreaks of congenital malformations in aborted and stillborn animals.
A Bridgen, A Bridgen, A Kohl, AC Lowen, AJ Della-Porta, Alain Kohl, Andrew Shaw, Anna Janowicz, AR Elbers, B Hoffmann, B Xu, CA Evans, Catherine Lamm, Claudio Murgia, CM Southam, CT Walter, D Thomas, DH Cybinski, Esther Schnettler, Eva McGregor, F Arnaud, Friedemann Weber, G Barry, G Blakqori, G Blakqori, G Neumann, Gerald Barry, Ilaria M. Piras, JI Gillespie, JL Farmer, K Kupferschmidt, K Peperkamp, K Terasaki, K Wernike, KE Jones, Kerstin Hahn, KV Goller, LD Rasmussen, M Beer, M Bouloy, M Caporale, M Dominguez, M Palmarini, M Ratinier, M Spiegel, M Varela, Mandy Glass, Marco Caporale, Mariana Varela, Martin Beer, Massimo Palmarini, Melanie McFarlane, MJ Killip, MM Garigliany, MM Garigliany, NR Saunders, OR Causey, P Vialat, PJ Hotez, PT Leisnham, R Muller, RS Azevedo, S Shimshony, SE Randolph, T Ikegami, T Yanase, UJ Buchholz, V Herder, Vanessa Herder, VH Leonard, Wolfgang Baumgärtner, X Shi, Y Ogawa, YK Liao   +73 more
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Chikungunya Virus Nonstructural Protein 2 Inhibits Type I/II Interferon-Stimulated JAK-STAT Signaling [PDF]

Journal of Virology, 2010
ABSTRACT Chikungunya virus (CHIKV) is an emerging human pathogen transmitted by mosquitoes. Like that of other alphaviruses, CHIKV replication causes general host shutoff, leading to severe cytopathicity in mammalian cells, and inhibits the ability of infected cells to respond to interferon (IFN).
Fros, J., Liu, W.J., Prow, A., Geertsema, C., Ligtenberg, M., Vanlandingham, D.L., Schnettler, E., Vlak, J.M., Suhrbier, A., Khromykh, A.A., Pijlman, G.P.   +10 more
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