Results 71 to 80 of about 27,042 (212)

The Osteoimmunologic Basis of Biologic and Bioengineered Scaffolds in Fracture Healing

Bioengineering
Fracture nonunion or delayed union remains a significant clinical problem that burdens both the patient and the healthcare system. Defined as failure for bone to unite 9 months post injury or 3 months with no progression toward union, the pathology of ...
Hannah Shelby, Sarah Bergren, Julian Wier, Edward M. Schwarz, Jay R. Lieberman   +4 more
doaj   +1 more source

Clinical and Radiologic Outcomes of NOVOSIS (rhBMP‐2 With Hydroxyapatite Carrier) Grafting for Scaphoid Waist Nonunion: A Preliminary Clinical Study

Orthopaedic Surgery, EarlyView.
NOVOSIS (rhBMP‐2 with hydroxyapatite carrier) grafting filled the scaphoid waist defect and promoted bone union after double headless screw fixation, offering a feasible alternative to autologous bone grafting. ABSTRACT Objective Scaphoid nonunion remains a challenging problem due to limited vascularity and carpal malalignment. Although autologous bone
Jisu Park, Ki Youn Kwon, Hyung Joon Ahn, Jin‐Rok Oh   +3 more
wiley   +1 more source

Reverse Versus Modified Judet Approach for Extra‐Articular Glenoid Neck and Scapular Body Fractures: A Retrospective Study

Orthopaedic Surgery, EarlyView.
This study shows that the reverse Judet approach provides functional results similar to the modified Judet approach in treating scapular fractures. Importantly, it greatly reduces the size of the incision and limits soft tissue dissection, which decreases surgical trauma. Therefore, the reverse Judet approach is a safe and effective option for treating
Qianxi Wang, Zehao Guo, Jingtian Shi, Mingfan Wu, Huai Jiang, Cong Sui, Yukang Que, Peng He, Yong Hu, Shenglin Xu   +9 more
wiley   +1 more source

A Novel 3D‐Printed Strut‐Type Prosthesis Reconstructs the Hemicortical Defect After Distal Femur Parosteal Osteosarcoma Resection: The Mid‐Term Follow‐Up Outcome

Orthopaedic Surgery, EarlyView.
This study developed a novel three‐dimensional (3D)‐printed strut‐type prosthesis for reconstruction of bone defects following hemicortical resection of distal femoral parosteal osteosarcoma. The mid‐term follow‐up results demonstrated that this prosthesis effectively restored limb function and exhibited favorable bone ingrowth and osseointegration ...
Jianhua Mu, Yitian Wang, Han Liu, Xuanhong He, Zhuangzhuang Li, Minxun Lu, Fan Tang, Yi Luo, Yong Zhou, Li Min, Chongqi Tu   +10 more
wiley   +1 more source

Nonunions of the humerus – Treatment concepts and results of the last five years

Chinese Journal of Traumatology, 2019
Purpose: Fractures of the humerus account for 5%–8% of all fractures. Nonunion is found with an incidence of up to 15%, depending on the location of the fracture.
Maximilian Leiblein, Rene Verboket, Ingo Marzi, Nils Wagner, Christoph Nau   +4 more
doaj   +1 more source

Development and Internal Evaluation of a Biomarker‐Based Model for Preoperative Diagnosis of Infectious Nonunion

Orthopaedic Surgery, EarlyView.
We developed and validated a biomarker‐based model (PCT, IL‐6, CRP, ESR) that accurately distinguishes infectious from aseptic nonunion in long bone fractures, enabling superior preoperative diagnosis and informed surgical decision‐making. ABSTRACT Objective Preoperative identification of infectious nonunion remains challenging, particularly in ...
Heng Wu, Jiahao Chen, Yu Lu, Xiao Ma, Haijian Li, Qiao Wu, Xiaodong Qi, Yuanjian Wu, Pei Han   +8 more
wiley   +1 more source

Factors associated with development of re-nonunion after primary revision in femoral shaft nonunion subsequent to failed intramedullary nailing

Journal of Orthopaedic Surgery and Research, 2018
Background Currently, there remains a lack of consensus regarding factors predictive of complication such as re-nonunion after primary revision in femoral shaft nonunion subsequent to failed intramedullary nailing (IMN).
Jiang-ying Ru, Li-xin Chen, Fang-yong Hu, Dai Shi, Rao Xu, Jian-wei Du, Yun-fei Niu   +6 more
doaj   +1 more source

Population level data on aging in periodontal and peri‐implant health—Aging is not a contraindication for periodontal or peri‐implant therapy

Periodontology 2000, EarlyView.
Abstract Objectives Global population aging is leading to a greater retention of natural teeth into later life and an increasing prevalence of dental implant therapy. Although advanced age has traditionally been regarded as a risk factor for compromised outcomes, population level evidence remains lacking.
Dong Yang, Jia Chang, Siyu Huang, Yvonne L. Kapila   +3 more
wiley   +1 more source

Multifunctional Bioactive Scaffold Facilitating BMSCs‐Driven Osteogenesis and Vascularization in Critical‐Sized Bone Defect Repair

Advanced Science, Volume 13, Issue 31, 4 June 2026.
A dual‐network bFGF@CB‐gel integrates: i) ChSMA scaffold (mechanical support/BMSCs delivery); ii) BC carrier (sustained bFGF release via EGFL/Itga2b and COMP/PI3K/AKT for adhesion/osteogenesis); iii) bFGF/PI3K/AKT/eNOS for angiogenesis. This rational, synergistic design addresses CSD bone regeneration challenges.
Yunze Feng, Bingzhi Chen, Yu Xu, Xin Xu, Bingtao Hu, Tongbo Li, Dingxin Zhang, Baoshuai Bai, Chen Liu, Wanlong Xu, Le Li, Wencan Zhang, Haipeng Si   +12 more
wiley   +1 more source

Injectable Porous Microspheres Loaded With Biomimetic Preconditioned Bone Marrow Mesenchymal Stem Cell‐Derived Exosomes for Vascularized Bone Regeneration

Advanced Science, Volume 13, Issue 32, 9 June 2026.
Schematic illustration of injectable PDA‐modified GelMA microspheres loaded with BioPre‐Exos for vascularized bone regeneration. ABSTRACT Critical‐sized bone defects remain a highly challenging clinical problem due to insufficient intrinsic self‐healing capacity.
Lijun Li, Hao Zhang, Lingtong Sun, Yingfeng Su, Yang Xu, Jian Huang, Jingchao Wen, Jinjin Zhu, Jianjun Ma, Wenbin Xu   +9 more
wiley   +1 more source