Noopept protects ciliates Paramecium сaudatum cells from the toxic effects of heavy metal compounds [PDF]
Фармакокинетика и Фармакодинамика, 2022 Background. The dipeptide drug Noopept, created at the Zakusov Institute of Pharmacology, has a wide range of pharmacological actions, including cytoprotective one.
O. V. Karpukhina +2 more
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Comparative study of pharmacokinetics and enzymatic resistance of the neuroprotective mean GZK-111 and noopept in rats [PDF]
Фармакокинетика и Фармакодинамика, 2022 The article presents the results of studying the pharmacokinetics and enzymatic stability of a new pharmacologically active compound GZK-111– N-phenylacetyl-glycyl-L-proline ethyl ether in comparison with noopept – N-phenylacetyl-L-prolyl-glycine ethyl ...
S. S. Boyko +2 more
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Morpho-functional parameters of neurons in the sensorimotor cortex and neuroapoptosis under conditions of an induced experimental allergic encephalomyelitis in rats and a course of intranasal gel administration containing n-phenylacetyl-l-prolylglycine (N [PDF]
Journal of Education, Health and Sport, 2021 Purpose. The aim of the research is to evaluate a neuroprotective effect of the nasal dosage form containing Noopept (n-phenylacetyl-l-prolylglycine ethyl ester) by the degree of influence on morphofunctional parameters of neurons in the sensorimotor ...
B. S. Burlaka +3 more
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Heliyon, 2021 There are largely unknown associations between changes in pain behavior responses during persistent peripheral inflammation and spinal cell alteration such as apoptosis.
Mona Taghizadeh +8 more
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Pharmacokinetics and neurotropic effects of cyclo-L-prolylglycine and its modified analogues [PDF]
Фармакокинетика и Фармакодинамика, 2022 The review presents the results of studies on the pharmacokinetics, metabolism, and bioavailability of new neurotropic dipeptide cyclo-Lprolilglycine (CPG) and their pharmacological activity.
S. S. Boyko +2 more
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A study on toxicity, local irritative effect of and allergic response to a novel intranasal medication containing N-phenylacetyl-L-prolylglycine ethyl ester [PDF]
Zaporožskij Medicinskij Žurnal, 2021 Development of novel medications for delivery of active ingredients with systemic absorption and high bioavailability is an actual challenge for modern pharmaceutical and medical science.
B. S. Burlaka, I. F. Bielenichev
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Neuroprotective properties of n-phenylacetyl-l-prolylglycine ethyl ester nasal gel in an experimental model of multiple sclerosis equivalent [PDF]
Medičnì Perspektivi, 2020 The purpose of this research is to study the specific activity of our developed nasal dosage form with n-phenylacetyl-l-prolylglycine ethyl ester. The experiments were performed on 260 white outbred rats weighing 190-220 g.
B.S. Burlaka +4 more
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Comparative pharmacokinetics and pharmacodinamics of noopept, its activity metabolite cycloprolylglycine and piracetam [PDF]
Фармакокинетика и Фармакодинамика, 2019 While studing of experimental pharmacokinetics of the peptide analogues piracetam noopept - N-phenylacetyl-L-prolyl-glycine ethyl ester, was found the active metabolite that identificated as cyclo-L-prolylglycine (CPG).
Svetlana Boyko +2 more
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The study of the permeability of the blood-brain barrier for new neurotropic peptide drugs [PDF]
Фармакокинетика и Фармакодинамика, 2019 The paper presents the results of studies of penetration through the hemato-encephalic barrier (BBB) of rats of three new peptide drugs -modified analogues of endogenous neuropeptides and their active metabolites created in the research Zakusov institute
V. P. Zherdev +2 more
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The Occurrence of Illicit Smart Drugs or Nootropics in Europe and Australia and Their Associated Dangers: Results from a Market Surveillance Study by 12 Official Medicines Control Laboratories [PDF]
Journal of XenobioticsIn recent years, an increasing number of case reports have mentioned the presence of illicit nootropics, smart drugs or mind doping products on the market.
Celine Vanhee +18 more
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