Results 151 to 160 of about 2,134 (194)

Mechanisms of retention of pyrrolidinyl norephedrine on immobilized ?1-acid glycoprotein

Chirality, 2000
The HPLC separation of the R,S and S,R enantiomers of pyrrolidinyl norephedrine on immobilized alpha-1 glycoprotein (AGP) was investigated. Conditions for the separation were varied using a premixed mobile phase containing an ammonium phosphate buffer and an organic modifier.
P M, Yehl, T P, O'Brien, C W, Moeder, N, Grinberg, G, Bicker, J, Wyvratt   +5 more
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[Pharmacokinetics of DL-norephedrine 14C in the rat].

Archives internationales de pharmacodynamie et de therapie, 1976
After i.v. administration of DL-norephedrine 14C to the rat (535 mug/kg), approximately 75% of the radioactivity was eliminated during the first 18 hr in the urine. Beside the unchanged drug (71.5% of the total urinary radioactivity), the main metabolite was alpha-methyloctopamine (18%), a parahydroxylated derivative of which 68% were excreted as ...
J F, Thiercelin, C, Jacquot, J R, Rapin, Y, Cohen   +3 more
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The Effects of Norephedrine and Bethanechol on the Human Urethral Closure Pressure Profile

Scandinavian Journal of Urology and Nephrology, 1978
In twelve women with urinary stress incontinence simultaneous measurements were made of the intravesical and intra-urethral pressures, including the urethral closure pressure profile (UCPP), before and after oral administration of norephedrine or subcutaneous injection of bethanechol.
A, Ek, K E, Andersson, U, Ulmsten
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Separation of the enantiomers of (±)-norephedrine by rotation locular counter-current chromatography

Journal of Chromatography A, 1982
Separation of the enantiomers of norephedrine by support-free liquid-liquid technique using roration locular counter-current chromatography were reported. In the experimnet carried out at 0o the two main maxima corresponding to the 1S- and 1-R enantiomers were observed.
Domon, Bruno, Hostettmann, Kurt, Kovačević, Krunoslav, Prelog, Vladimir   +3 more
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A new norephedrine-derived chiral base for epoxide rearrangement reactions

Tetrahedron Letters, 1999
Abstract The conversion of (1 R ,2 S )-norephedrine into a novel chiral diamine (83% yield, simple two step synthesis) and its use as a chiral base in two epoxide rearrangement reactions is reported. Rearrangement of a 4,5-disubstituted cyclohexene oxide and of a 4-aminosubstituted cyclopentene oxide generated allylic alcohols of >90% ee.
Simon E de Sousa, Peter O'Brien, H.Christian Steffens   +2 more
openaire   +1 more source

Synthesis and stereochemical analysis of some norephedrine‐derived isoxazolidines

Journal of Physical Organic Chemistry, 2008
AbstractThe diastereoselectivity in the cycloaddition reactions of several mono‐ and disubstituted alkenes with a (‐)norephedrine‐derived methylenenitrone has been investigated. The stereochemical analysis of the addition products (i.e., isoxazolidines) has been carried out by X‐ray, NMR, and chemical conversions.
Basem A. Moosa, Mohamed I. M. Wazeer, Mohammed B. Fettouhi, Shaikh A. Ali   +3 more
openaire   +1 more source

Design of scytalone dehydratase inhibitors as rice blast fungicides: Derivatives of norephedrine

Bioorganic & Medicinal Chemistry Letters, 1999
Five X-ray crystal structures of scytalone dehydratase complexed with different inhibitors have delineated conformationally flexible regions of the binding pocket. This information was used for the design and synthesis of a norephedrine-derived cyanoacetamide class of inhibitors leading to potent fungicides.
G S, Basarab, D B, Jordan, T C, Gehret, R S, Schwartz, Z, Wawrzak   +4 more
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Highly stereoselective acetylations via norephedrine derived oxazolidines.

Tetrahedron, 1991
Abstract Norephedrine derived 2-methoxy-2-methyl oxazolidine 2 is an efficient stereoselective acetylating agent in reactions with stereogenic silylenolethers and silylketenethiolacetals. Moderate selectivity is also obtained upon acetylation of crotyltin reagents.
Anna Bernardi, Marcello Cavicchioli, Giovanni Poli, Carlo Scolastico, Atanas Sidjimov   +4 more
openaire   +1 more source

Effects of oral norephedrine on common cold symptoms.

Rhinology, 1983
The aim of the trial was to examine the effectiveness of an oral decongestant in common cold. Thirty subjects with naturally acquired colds got a 100 mg sustained release tablet containing norephedrine on one day and a placebo tablet on another day in double blind design.
H, Grønborg, B, Winther, S, Brofeldt, P, Borum, N, Mygind   +4 more
openaire   +1 more source

The fate of amphetamine and norephedrine in the Tamarin monkey compared with man.

West African journal of pharmacology and drug research, 1976
When [14C] (+/-)-amphetamine sulphate (0.3 mg/kg) was injected into Tamarin monkeys, some 70-80% of the 14C was excreted in the urine in 24 hours. Some 75% of the 24-hour excretion was unchanged drug, 7% was free and conjugated benzoic acid and 7% was hydroxylated in the aromatic ring to give mainly 4-hydroxyamphetamine (Paredrine).
L G, Dring, R B, Franklin, R T, Williams
openaire   +1 more source