Results 1 to 10 of about 131,238 (161)

Sustained chemogenetic activation of locus coeruleus norepinephrine neurons promotes dopaminergic neuron survival in synucleinopathy

open access: yesPLoS ONE, 2022
Dopaminergic neuron degeneration in the midbrain plays a pivotal role in motor symptoms associated with Parkinson’s disease. However, non-motor symptoms of Parkinson’s disease and post-mortem histopathology confirm dysfunction in other brain areas ...
Predrag Jovanovic   +7 more
doaj   +2 more sources

Arterial Hypotension Following Norepinephrine Decrease in Septic Shock Patients Is Not Related to Preload Dependence: A Prospective, Observational Cohort Study

open access: yesFrontiers in Medicine, 2022
BackgroundThe optimal management of hypotensive patients during norepinephrine weaning is unclear. The primary study aim was to assess the ability of preload dependence to predict hypotension following norepinephrine weaning.
Stefan Andrei   +8 more
doaj   +1 more source

Evaluating intraoperative norepinephrine versus fresh frozen plasma in patients undergoing cytoreductive surgery and HIPEC to reduce renal insult

open access: yesEgyptian Journal of Anaesthesia, 2022
Objective This study aims to compare the efficacy of intraoperative norepinephrine infusion versus plasma in reducing renal insult during cytoreductive surgeries.Methods Sixty patients (ASA I–III) of both genders were included in the study. Plasma group:
Mohamed Adly   +3 more
doaj   +1 more source

Norepinephrine use in cardiogenic shock patients is associated with increased 30 day mortality

open access: yesESC Heart Failure, 2022
Aims Norepinephrine is recommended as a first‐line vasopressor agent in the haemodynamic stabilization of cardiogenic shock. The survival benefit of norepinephrine therapy has not been demonstrated in clinical practice, however.
Xin Lu   +8 more
doaj   +1 more source

Determination of the Relative Potency of Norepinephrine and Phenylephrine Given as Infusions for Preventing Hypotension During Combined Spinal-Epidural Anesthesia for Cesarean Delivery: A Randomized Up-And-Down Sequential Allocation Study

open access: yesFrontiers in Pharmacology, 2022
Purpose: The relative potency of norepinephrine and phenylephrine given as boluses to treat hypotension during spinal anesthesia for cesarean delivery has been reported but few data are available for infusions.
Jing Qian   +13 more
doaj   +1 more source

Comparison of two Norepinephrine rescue bolus for Management of Post-spinal Hypotension during Cesarean Delivery: a randomized controlled trial

open access: yesBMC Anesthesiology, 2020
Background Data on the best norepinephrine bolus dose for management of hypotension are limited. The aim of this study was to compare the efficacy and safety of two norepinephrine bolus doses in the rescue management of maternal hypotension during ...
Yasmin S. Hassabelnaby   +11 more
doaj   +1 more source

Comparison of two vasopressor protocols for preventing hypotension post-spinal anesthesia during cesarean section: a randomized controlled trial

open access: yesChinese Medical Journal, 2021
. Background:. Norepinephrine infusion decreases hypotension after spinal anesthesia during cesarean section. This study aimed to compare the efficacy of norepinephrine infusion and ephedrine bolus against post-spinal hypotension in parturients. Methods:.
Qian-Qian Fan   +11 more
doaj   +1 more source

Impact of locus coeruleus and its projections on memory and aging [PDF]

open access: yes, 2021
Introduction: Locus coeruleus (LC) is the primary source of norepinephrine to the brain and its efferent projections innervate many brain regions, including the thalamus. LC degrades with normal aging, but not much is known regarding whether its structural connectivity evolves with age or predicts aspects of cognition.
arxiv   +1 more source

Mobilisation of critically ill patients receiving norepinephrine: a retrospective cohort study

open access: yesCritical Care, 2022
Background Mobilisation and exercise intervention in general are safe and feasible in critically ill patients. For patients requiring catecholamines, however, doses of norepinephrine safe for mobilisation in the intensive care unit (ICU) are not defined.
Maximilian Lindholz   +12 more
doaj   +1 more source

Interactions Between Experience, Genotype and Sex in the Development of Individual Coping Strategies

open access: yesFrontiers in Behavioral Neuroscience, 2021
Coping strategies, the first line of defense against adversities, develop through experience. There is consistent evidence that both genotype and sex contribute to the development of dysfunctional coping, leading to maladaptive outcomes of adverse ...
Rossella Ventura   +9 more
doaj   +1 more source

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