Advanced Science, EarlyView.Inspired by the composition and structure of native bone tissue and its complex interplay of biological signals, a norepinephrine‐loaded biomimetic mineralized electrocompacted collagen scaffold (NE‐MEC) is developed capable of simultaneously supporting osteogenesis, neural repair, angiogenesis, and immune modulation.
Zhengyun Ren +10 more
openalex +2 more sources
Effect of methylphenidate treatment during adolescence on norepinephrine transporter function in orbitofrontal cortex in a rat model of attention deficit hyperactivity disorder [PDF]
, 2015 Attention deficit hyperactivity disorder (ADHD) is associated with hypofunctional medial prefrontal cortex (mPFC) and orbitofrontal cortex (OFC). Methylphenidate (MPH) remediates ADHD, in part, by inhibiting the norepinephrine transporter (NET). MPH also
Dwoskin, Linda P. +2 more
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Annals of Intensive Care, 2022 Background Excess exposure to norepinephrine can compromise microcirculation and organ function. We aimed to assess the association between norepinephrine exposure and acute kidney injury (AKI) and intensive care unit (ICU) mortality after cardiac ...
Pierre Huette +11 more
doaj +1 more source
A cautionary note for researchers treating mice with the neurotransmitter norepinephrine
Biochemistry and Biophysics Reports, 2018 The sympathetic nervous system plays a crucial role in metabolic function and glucose homeostasis. Norepinephrine is the main neurotransmitter released from sympathetic neurons. The major goal of our studies was to examine the impact of norepinephrine on
Vance B. Matthews +2 more
doaj +1 more source
Organic Cation Transporter 3: A Cellular Mechanism Underlying Rapid, Non-Genomic Glucocorticoid Regulation of Monoaminergic Neurotransmission, Physiology, and Behavior [PDF]
, 2018 Corticosteroid hormones act at intracellular glucocorticoid receptors (GR) and mineralocorticoid receptors (MR) to alter gene expression, leading to diverse physiological and behavioral responses.
Gasser, Paul J., Lowry, Christopher A.
core +2 more sources
Journal of Immunology Research, 2021 Objective/Background and Aims. The gastrointestinal tract is rich in neurotransmitters, which play an essential role in the occurrence and development of gastrointestinal tumors. We aimed to explore the function of neurotransmitters in gastric cancer and
Yangyang Wang +5 more
doaj +1 more source
Norepinephrine-evoked pain in fibromyalgia. A randomized pilot study [ISRCTN70707830]
BMC Musculoskeletal Disorders, 2002 Background Fibromyalgia syndrome displays sympathetically maintained pain features such as frequent post-traumatic onset and stimuli-independent pain accompanied by allodynia and paresthesias.
Casanova Jose-Miguel +5 more
doaj +1 more source
Case Reports in Critical Care, 2014 Background. During hypertensive therapy for post-subarachnoid hemorrhage (SAH) symptomatic vasospasm, norepinephrine is commonly used to reach target blood pressures. Concerns over aggravation of vasospasm with norepinephrine exist. Objective.
F. A. Zeiler +4 more
doaj +1 more source
Iodine-123 labeled reboxetine analogues for imaging of noradrenaline transporter in brain using single photon emission computed tomography [PDF]
, 2012 Preliminary investigation of the radioiodinated (S,S)-reboxetine analogue, 123I-INER, in baboons showed this tracer to have promise for imaging the noradrenaline transporter (NAT) using single photon emission computed tomography (SPECT).
Baldwin +26 more
core +1 more source
Pik3r1 Is Required for Glucocorticoid-Induced Perilipin 1 Phosphorylation in Lipid Droplet for Adipocyte Lipolysis. [PDF]
, 2017 Glucocorticoids promote lipolysis in white adipose tissue (WAT) to adapt to energy demands under stress, whereas superfluous lipolysis causes metabolic disorders, including dyslipidemia and hepatic steatosis. Glucocorticoid-induced lipolysis requires the
Broughton, Augusta E +6 more
core +1 more source