Results 41 to 50 of about 316,132 (386)

Norepinephrine enhances the LPS-induced expression of COX-2 and secretion of PGE2 in primary rat microglia

open access: yesJournal of Neuroinflammation, 2010
Background Recent studies suggest an important role for neurotransmitters as modulators of inflammation. Neuroinflammatory mediators such as cytokines and molecules of the arachidonic acid pathway are generated and released by microglia.
Candelario-Jalil Eduardo   +6 more
doaj   +1 more source

Preclinical discovery of duloxetine for the treatment of depression [PDF]

open access: yes, 2012
Introduction: Affective disorders, including major depressive disorder (MDD), are among the most severely disabling mental disorders, and in many cases areIntroduction: Affective disorders, including major depressive disorder (MDD), are among the most ...
Berrocoso Domínguez, Esther María   +4 more
core   +2 more sources

A High-Affinity Fluorescent Sensor for Catecholamine: Application to Monitoring Norepinephrine Exocytosis.

open access: yesAngewandte Chemie, 2019
A fluorescent sensor for catecholamines, NS510, is presented. The sensor is based on a quinolone fluorophore incorporating a boronic acid recognition element that gives it high affinity for catecholamines and a turn-on response to norepinephrine.
Le Zhang   +3 more
semanticscholar   +1 more source

Plasma norepinephrine and mortality [PDF]

open access: yesClinical Cardiology, 1995
Plasma norepinephrine levels, which reflect sympathetic nervous system activity, are almost universally elevated in patients with left ventricular dysfunction. This elevation occurs in patients with overt, symptomatic heart failure (HF) and in patients with asymptomatic left ventricular dysfunction.
openaire   +2 more sources

Effect of ketone bodies on lipolysis in adipose tissue in vitro

open access: yesJournal of Lipid Research, 1966
Norepinephrine-sensitive lipase activity was measured in rat epididymal fat pads by determining release either of free fatty acids or of glycerol.
Per Björntorp
doaj   +1 more source

Low-dose norepinephrine in combination with hypotensive resuscitation may prolong the golden window for uncontrolled hemorrhagic shock in rats

open access: yesFrontiers in Physiology, 2022
Hypotension resuscitation is an important principle for the treatment after trauma. Current hypotensive resuscitation strategies cannot obtain an ideal outcome for remote regions.
Yuanqun Zhou   +7 more
doaj   +1 more source

Pik3r1 Is Required for Glucocorticoid-Induced Perilipin 1 Phosphorylation in Lipid Droplet for Adipocyte Lipolysis. [PDF]

open access: yes, 2017
Glucocorticoids promote lipolysis in white adipose tissue (WAT) to adapt to energy demands under stress, whereas superfluous lipolysis causes metabolic disorders, including dyslipidemia and hepatic steatosis. Glucocorticoid-induced lipolysis requires the
Broughton, Augusta E   +6 more
core   +1 more source

Low Dosing Norepinephrine Effects on Cerebral Oxygenation and Perfusion During Pediatric Shock

open access: yesFrontiers in Pediatrics, 2022
BackgroundCerebral hypoperfusion and impaired oxygen delivery during pediatric critical illness may result in acute neurologic injury with subsequent long-term effects on neurodevelopmental outcome.
Meryl Vedrenne-Cloquet   +6 more
doaj   +1 more source

The Action of Norepinephrine, Epinephrine and Isopropyl Norepinephrine on the Rhythmic Function of the Heart [PDF]

open access: yesCirculation, 1952
The actions of norepinephrine and isopropyl norepinephrine on the rhythmic property of the heart were studied and compared with that of epinephrine. Norepinephrine does not abolish cardiac standstill by carotid sinus stimulation, has no effect on the ventricular rate of heart block and induces a sinus bradycardia.
Morris H. Nathanson, Harold Miller
openaire   +3 more sources

Norepinephrine affects the interaction of adherent-invasive Escherichia coli with intestinal epithelial cells

open access: yesVirulence, 2021
Norepinephrine (NE), the stress hormone, stimulates many bacterial species’ growth and virulence, including Escherichia coli. However, the hormone’s impact on the adherent-invasive E. coli (AIEC) implicated in Crohn’s disease is poorly understood. In the
Sobieszczańska Beata   +6 more
doaj   +1 more source

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