Results 61 to 70 of about 1,909 (140)
Large prebiotic molecules in space: photo-physics of acetic acid and its isomers [PDF]
, 2009 An increasing number of large molecules have been positively identified in space. Many of these molecules are of biological interest and thus provide insight into prebiotic organic chemistry in the protoplanetary nebula. Among these molecules, acetic acid is of particular importance due to its structural proximity to glycine, the simplest amino acid ...
arxiv +1 more source
Sphingosine 1‐phosphate receptor modulators in multiple sclerosis treatment: A practical review
Annals of Clinical and Translational Neurology, Volume 11, Issue 4, Page 842-855, April 2024.Abstract Four sphingosine 1‐phosphate (S1P) receptor modulators (fingolimod, ozanimod, ponesimod, and siponimod) are approved by the US Food and Drug Administration for the treatment of multiple sclerosis. This review summarizes efficacy and safety data on these S1P receptor modulators, with an emphasis on similarities and differences.
Patricia K. Coyle +4 more
wiley +1 more source
F&S Reports, 2023 Treatment of uterine fibroids (UF) and endometriosis (EM) has relied on the surgical skills of gynecologists to improve symptoms and potentially alter the course of these debilitating diseases.
Juan C. Arjona Ferreira, M.D. +1 more
doaj
CPT: Pharmacometrics &Systems Pharmacology, Volume 13, Issue 4, Page 563-575, April 2024.Abstract Considerable interest remains across the pharmaceutical industry and regulatory landscape in capabilities to model oral contraceptives (OCs), whether combined (COCs) with ethinyl estradiol (EE) or progestin‐only pill. Acceptance of COC drug–drug interaction (DDI) assessment using physiologically‐based pharmacokinetic (PBPK) is often limited to
Gareth J. Lewis +2 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 30, Issue 4, April 2024.We have demonstrated metabolic markers in CSF associated with the classification of SMA in children, including 4‐chlorophenylacetic acid, sodium dodecyl benzenesulfonate, and cinobufagin. We also identified the metabolic pathways associated with the severity of SMA, including lysine degradation, arginine metabolism, and tyrosine metabolism.
Mengnan Lu +5 more
wiley +1 more source
Multiphasic pH profiles for the reaction of tris-(hydroxymethyl)-aminomethane with phenyl esters [PDF]
arXiv, 2015 Reanalysis of data (Bruice and York 1961) for the pH dependences of the calculated apparent second-order rate constants (k2) for the reaction of tris-(hydroxymethyl)-aminomethane (TRIS) with phenyl esters reveals that the pH profiles are consistently much better represented as multiphasic, i.e. as a series of straight lines separated by discontinuities
arxiv
Reproductive Medicine and Biology, Volume 23, Issue 1, January/December 2024.Abstract Background Endometriosis is a common gynecological disease affecting women of reproductive age. Patients with endometriosis frequently experience severe chronic pain and have higher chances to experience infertility. Progesterone resistance is a major problem that develops during the medical treatment of endometriosis, which often leads to ...
Hsiao‐Chien Tang +3 more
wiley +1 more source
Acetone as a Polar Cosolvent for Pyridinium-Based Ionic Liquids [PDF]
arXiv, 2015 The work reports transport and structure properties of the three pyridinium-based ionic liquids (RTILs) - N-butylpyridinium hexafluorophosphate [BPY][PF6], N-butylpyridinium trifluorosulfonate [BPY][TF] and N-butylpyridinium bis(trifluoromethanesulfonyl)imide [BPY][TFSI] - in their mixtures with acetone (ACET).
arxiv
WIREs Forensic Science, Volume 6, Issue 1, January/February 2024.Although anabolic–androgenic steroid (AAS) use is increasing within the general population, detection of these compounds within forensic laboratories remains limited. It is therefore important to consider what substances are used, how they are administered and which are the most suitable analytical techniques for detection within the forensic context ...
Richard L. Harries +3 more
wiley +1 more source
The genealogical tree of ethanol: gas-phase formation of glycolaldehyde, acetic acid and formic acid [PDF]
, 2017 Despite the harsh conditions of the interstellar medium, chemistry thrives in it, especially in star forming regions where several interstellar complex organic molecules (iCOMs) have been detected. Yet, how these species are synthesised is a mystery. The majority of current models claim that this happens on interstellar grain surfaces.
arxiv +1 more source