Results 61 to 70 of about 401,712 (176)

Transfer of the Oral Gonadotropin‐Releasing Hormone Receptor Antagonist Relugolix Into Breast Milk of Healthy Lactating Women

Pharmacology Research &Perspectives, Volume 13, Issue 1, February 2025.
Relugolix concentration/time profiles in breast milk of lactating women. ABSTRACT Relugolix is an oral gonadotropin‐releasing hormone receptor antagonist that suppresses sex steroid hormones and is approved as monotherapy for prostate cancer and as a fixed‐dose combination with estradiol/norethindrone for the treatment of endometriosis and uterine ...
Darin B. Brimhall, Yu‐Luan Chen, Sarah Lee, Kazumasa Yoshida, Mike Ufer   +4 more
wiley   +1 more source

Standard Protocols for Characterising Primary and In Vitro‐Generated Human Hepatocytes

Journal of Cellular and Molecular Medicine, Volume 29, Issue 3, February 2025.
ABSTRACT Hepatocyte‐like cells (HLCs) derived from pluripotent stem cells (PSCs) or direct reprogramming are an unlimited source of human hepatocytes for biomedical applications. HLCs are used to model human diseases, develop precise drugs and establish groundbreaking regenerative cell‐based therapies.
Zahra Heydari, Roberto Gramignoli, Abbas Piryaei, Ensieh Zahmatkesh, Paria Pooyan, Homeyra Seydi, Andreas Nussler, Dagmara Szkolnicka, Hassan Rashidi, Mustapha Najimi, David C. Hay, Massoud Vosough   +11 more
wiley   +1 more source

The effect of Norethisterone acetate on the uterus of albino rats: histological, histochemical and ultrastructure study

BMC Veterinary Research
Background Norethisterone acetate (NETA), also known as norethindrone acetate is a progestogens medication that is widely used in birth control pills, menopausal hormone therapy, and for the treatment of gynecological disorders as abnormal uterine ...
Mahmoud Abd-Elkareem, Sulaiman Mohammed Alnasser, Alotaibi Meshal, Raghda Ismail Abdullah, Ahmed U. Ali   +4 more
doaj   +1 more source

Relugolix Combination Tablets in Healthy Japanese Premenopausal Women: Pharmacokinetics, Pharmacodynamics, and Safety Profile

Reproductive Medicine and Biology, Volume 24, Issue 1, January/December 2025.
ABSTRACT Purpose To evaluate the applicability of overseas‐approved dosage of relugolix combination tablets (relugolix 40 mg, estradiol [E2] 1 mg, and norethisterone acetate 0.5 mg) in healthy premenopausal Japanese women. Methods A randomized, double‐blind phase I/II study was conducted to compare the pharmacokinetics, pharmacodynamics, and safety of ...
Yutaka Osuga, Hiroyasu Hozumi, Masaki Fujisawa, Kazuhiro Shimomiya, Rieko Azuma   +4 more
wiley   +1 more source

The natural evolution of untreated deep endometriosis and the effect of hormonal suppression: A systematic literature review and meta‐analysis

Acta Obstetricia et Gynecologica Scandinavica, Volume 103, Issue 9, Page 1722-1735, September 2024.
The overall estimate of the percentage of deep endometriotic lesion progression over time in untreated individuals was 21.4%, whereas it was 12.4% during various hormonal treatments. The potential serious complications of uncontrolled lesion progression, such as bowel occlusion and ureteral stenosis with kidney failure should be taken into account ...
Veronica Bandini, Francesca Giola, Deborah Ambruoso, Sonia Cipriani, Francesca Chiaffarino, Paolo Vercellini   +5 more
wiley   +1 more source

Clinical pharmacology considerations and drug–drug interactions with long‐acting cabotegravir and rilpivirine relevant to sub‐Saharan Africa

British Journal of Clinical Pharmacology, Volume 90, Issue 9, Page 2079-2091, September 2024.
Long‐acting injectable (LAI) cabotegravir and rilpivirine for HIV treatment and LAI cabotegravir for pre‐exposure HIV prophylaxis are being rolled out in a multitude of countries worldwide. Due to the prolonged exposure, it can be challenging to undertake ‘traditional’ pharmacokinetic studies and current guidance is derived from their oral equivalents ...
Adrian Steulet, Bonniface Obura, Catriona Waitt, Eva Laker, Melanie R. Nicol, Fiona V. Cresswell   +5 more
wiley   +1 more source

The influence of oral contraceptives on the exercise pressor reflex in the upper and lower body

Physiological Reports, Volume 12, Issue 13, July 2024.
Abstract Previous research has demonstrated that oral contraceptive (OC) users have enhanced cardiorespiratory responses to arm metaboreflex activation (i.e., postexercise circulatory occlusion, PECO) and attenuated pressor responses to leg passive movement (PM) compared to non‐OC users (NOC).
T. J. Pereira, H. Edgell
wiley   +1 more source

Impact of demographic and clinical factors on elagolix plus add-back therapy effects on patient-reported nonbleeding symptoms in women with heavy menstrual bleeding and uterine fibroids: a post hoc analysis of data from two clinical trials

F&S Reports
Objective: To investigate the efficacy of elagolix plus add-back therapy (estradiol [1 mg] and norethindrone acetate [0.5 mg] once daily) on patient-reported nonbleeding symptoms and menstrual bleeding associated with uterine fibroids (UFs) across ...
James A. Simon, M.D., Elizabeth A. Stewart, M.D., Susan Jewell, Ph.D., Moming Li, Ph.D., Michael C. Snabes, M.D., Ph.D.   +4 more
doaj   +1 more source

Presurgical treatment of uterine myomas with the GnRH-antagonist relugolix in combination therapy: an observational study

Scientific Reports
To evaluate if a preoperative medical treatment with the GnRH-antagonist relugolix in combination therapy in a series of patients with abnormal uterine bleeding associated with uterine myomas may correct the anemia before scheduled surgery for myoma ...
Ludovico Muzii, Giulia Galati, Antonella Mercurio, Carlotta Olivieri, Letizia Scarcella, Ilham Azenkoud, Rossana Tripodi, Michele Vignali, Stefano Angioni, Antonio Maiorana   +9 more
doaj   +1 more source

The impact of progestogens on RAAS – a systematic review

BMC Women's Health
Background Progestogens, synthetic analogues of progesterone, are widely used in clinical practice for contraception, hormone replacement therapy, and the management of gynecological disorders. Understanding the specific impacts of different progestogens
Adrian Singer, Katharina Tropschuh, Marc von Gernler, Claire Decrinis, Petra Stute   +4 more
doaj   +1 more source