Results 61 to 70 of about 515 (110)
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Metabolism of norethynodrel by rat liver
Biochemical Pharmacology, 1971Abstract The incubation in vitro of norethynodrel with the postmitochondrial supernatant from rat liver results in the formation of three intermediary metabolites, namely the 3α- and 3β-hydroxy derivatives and norethindrone. These three steroids are further metabolized to more polar compounds thought to be polyhydroxylated end-products. Incubation of
Ronald Rosenfeld, M E Wall, C E Cook
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Thromboembolic Disease Associated With Norethynodrel
JAMA - Journal of the American Medical Association, 1964In a single institution during a 14-month period, thromboembolic disease occurred in six women who had been taking norethynodrel, thrombophlebitis was observed in three patients and pulmonary infarction in two, and an arterial occlusion in one patient resulted in the loss of a lower extremity.
Irwin J Schatz
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The link between norethynodrel and thromboembolism
American Journal of Obstetrics and Gynecology, 1964Abstract Two cases of pulmonary embolism following the use of norethynodrel are presented. The link between norethynodrel and thromboembolism may exist wherein norethynodrel by virtue of its strong estrogenic effect alters adrenal cortical hormone metabolism sufficiently to cause vasculitis, increased coagulability and thrombosis in susceptible ...
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Norethynodrel binding to human plasma proteins
The Journal of Steroid Biochemistry, 1975The binding of norethynodrel to human plasma proteins was investigated. Plasma and plasma proteins from normal men women and pregnant women were studied. It was seen that undilute plasma binds norethynodrel to the extent of 94-95% Plasma diluted to 20 times was able to bind 65-72% of norethynodrel and dilution of female plasma to 40 times showed 54 ...
K R Laumas, K R Laumas
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Effect of norethynodrel on endometriosis
American Journal of Obstetrics and Gynecology, 1961The authors selected norethynodrel for conservative therapy beginning in 1958 because of the hormones lack of androgenic effect inhibition of ovulation and estrogenic effect. Minimal duration of therapy was planned to be 6 months. By 1960 there were 123 patients diagnosed at Walter Reed General Hospital as having endometriosis and suitable for this ...
H L, RIVA, J H, WILSON, D M, KAWASAKI
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Norethynodrel-Mestranol and Thyroid Function
The Journal of Clinical Endocrinology & Metabolism, 1966Indices of thyroid function were measured in 10 euthyroid females after equilibration to each of 3 treatments: (a) without medication, (b) while taking 250 μg thyroxine daily, and (c) while taking 250 μg thyroxine and 10 mg norethynodrel-mestranol daily. The thyroidal radioiodine clearance rate decreased from treatment (a) to treatment (b).
D A, Fisher, T H, Oddie, D, Epperson
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THE USE OF NORETHYNODREL IN PSYCHOTIC FEMALES
American Journal of Psychiatry, 1964postpartum interval and pre-menstrually. Frank( 1931) reported that sterilizing irradiation of the ovaries afforded relief of such diverse pre-menstrual symptoms as convulsions, asthma and depression. He concluded the symptoms resulted from an excess of hormone and in the milder cases attempted to increase the rate of excretion of this excess by the ...
D W, SWANSON +3 more
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NORETHYNODREL AND MESTRANOL (ENAVID) IN THE PREVENTION OF RECURRENT ABORTION
Lancet, The, 1965exaly +3 more sources