Results 151 to 160 of about 1,822 (206)

METABOLISM OF [14C]NORGESTREL IN MAN

Journal of Endocrinology, 1968
SUMMARY [14C]Norgestrel was administered to seven human subjects and 43% of dose was excreted in the urine within 5 days; the biological half-life of the radioactivity was 24 hr. Enzymic hydrolysis released only 32% of the the urinary radioactivity and a further 25% was excreted as sulphate conjugates.
P, Littleton, K, Fotherby, K J, Dennis
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Automated colorimetric assay of Norgestrel

Steroids, 1970
Abstract A relatively sensitive assay for the contraceptive steroid norgestrel, in pharmaceutical preparations, is described. The procedure involves the blue tetrazolium reaction. Optimum conditions for color development were established. The relative standard deviation for the assay, which has a sample rate of 30 hr−1, were of the order of 0.9% at a
P M, Short, C T, Rhodes
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Totalsynthese von (–)‐Norgestrel

Helvetica Chimica Acta, 1985
Total‐Synthesis of (–)‐Norgestrel(–)‐Norgestrel (1a) or (–)‐norethindrone (1b), two active progestational ingredients of currently used contraceptives have been synthesized stereoselectively. Compound 1a has been obtained starting from m‐cresol methyl ether, dimethyl malonate, and (E)‐1,4‐dibromo‐2‐butene.
Helmut Baier, Gerd Dürner, Gerhard Quinkert   +2 more
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RADIOIMMUNOASSAY OF SYNTHETIC PROGESTOGENS, NORETHISTERONE AND NORGESTREL

Journal of Endocrinology, 1974
SUMMARY Antibodies to norethisterone and norgestrel were raised in rabbits by injecting the steroid 3-carboxymethyloxime coupled to bovine serum albumin. Within 6 months of the first injection, antisera were obtained which gave 50% binding of the labelled steroid at dilutions of 1:100000; after treatment with Rivanol the antisera had ...
R J, Warren, K, Fotherby
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Peripheral plasma levels of d-norgestrel in women after oral administration of d-norgestrel and when using intravaginal rings impregnated with dl-norgestrel

Contraception, 1975
Abstract Peripheral plasma levels of progesterone, estradiol and d-norgestrel were determined by radioimmunoassay in five women using silastic intravaginal rings (IVR), homogenously impregnated with 50 mg of dl-norgestrel and in three women after oral intake of 250 and 30 μg of d-norgestrel.
A, Victor, L E, Edqvist, P, Lindberg, K, Elamsson, E D, Johansson   +4 more
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Improvement of a d-norgestrel-releasing IUD

Contraception, 1977
Abstract A d-norgestrel-releasing IUD was introduced into the uterine cavity of-18 healthy women. The carrier material for d-norgestrel was silastic ® attached to the vertical arm of a Nova-T. Two kinds of d-norgestrel IUDs were used, with d-norgestrel-releasing surface areas of 83 mm 2 and 132 mm 2 , respectively.
C.G. Nilsson, T. Luukkainen
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Sustained intrauterine release of d-norgestrel

Contraception, 1978
Clinical experience with seventy-two first insertions of a d-norgestrel-releasing IUD is reported. Plasma d-norgestrel concentrations were measured in twelve subjects. No pregnancies occurred in the 522 woman-months of use (averaging 7.3 months/subject) that have been accumulated. Removals were performed in six subjects for medical reasons and in seven
T, Luukkainen, C G, Nilsson
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URINARY METABOLITES OF DL-NORGESTREL IN WOMEN

Acta Endocrinologica, 1973
ABSTRACT Urines obtained from women administered the totally synthetic progestational steroid, 14C-dl-norgestrel, were fractionated on DEAE-Sephadex A-25. This anion exchanger separated unchanged norgestrel and ether extractable metabolites (6.5–10.2 % of the urinary radioactivity) as well as neutral, non-extractable metabolites (4.0–12.3 % of ...
S P, Sisenwine, H B, Kimmel, A L, Liu, H W, Ruelius   +3 more
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The conversion of -norgestrel-3-oxime-17-acetate to -norgestrel in female rhesus monkeys

Contraception, 1977
Abstract Single intragastric 0.5 mg/kg doses of 14 C-d-norgestrel-3-oxime-17-acetate were given to female rhesus monkeys. Rapid absorption was evidenced by peak concentrations of radioactivity in plasma and whole blood within three hours. A multiphasic decline in concentrations of radioactivity then followed.
S F, Sisenwine, A L, Liu, H B, Kimmel, H W, Ruelius   +3 more
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Binding of norgestrel to human plasma proteins

Biochimica et Biophysica Acta (BBA) - Protein Structure, 1976
Binding of [14, 15-3H](+/-)-norgestrel to human plasma proteins has been investigated. Norgestrel showed greater affinity to plasma than to human serum albumin indicating specific norgestrel binding protein(s) in the plasma. alpha1-acid glycoprotein showed high affinity for norgestrel when compared with human serum albumin.
J P, Uniyal, K R, Laumas
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