Results 41 to 50 of about 3,430 (196)

Single‐Cell RNA‐Seq Reveals Aging‐Related Impairment of Microglial Efferocytosis Contributing to Apoptotic Cells Accumulation After Retinal Injury

Aging Cell, Volume 24, Issue 8, August 2025.
Microglia engage with apoptotic cells via cell‐surface receptors, such as proto‐oncogene tyrosine‐protein kinase MER (MerTK) and Axl; these receptors interact with the bridging molecule growth arrest‐specific 6 (Gas6) on apoptotic cells. Young microglia demonstrate efficient efferocytosis of apoptotic cells, but this process is impaired in aged ...
Pan Liu, Qi Wang, Shuimiao Wang, Ying Liu, Qiqi Chen, Wanyun Qin, Xinna Liu, Xinqi Ye, Yexuan Jiao, Huiping Yuan, Zhengbo Shao   +10 more
wiley   +1 more source

European S2k guidelines for hidradenitis suppurativa/acne inversa part 2: Treatment

Journal of the European Academy of Dermatology and Venereology, Volume 39, Issue 5, Page 899-941, May 2025.
HS treatment algorithm. Abstract Introduction This second part of the S2k guidelines is an update of the 2015 S1 European guidelines. Objective These guidelines aim to provide an accepted decision aid for the selection, implementation and assessment of appropriate and sufficient therapy for patients with hidradenitis suppurativa/acne inversa (HS ...
C. C. Zouboulis, F. G. Bechara, F. Benhadou, V. Bettoli, Z. Bukvić Mokos, V. Del Marmol, M. Dolenc‐Voljč, E. J. Giamarellos‐Bourboulis, Ø. Grimstad, P. Guillem, B. Horváth, R. E. Hunger, J. R. Ingram, D. Ioannidis, E. Just, L. Kemény, B. Kirby, A. I. Liakou, B. M. McGrath, A. V. Marzano, Ł. Matusiak, A. Molina‐Leyva, A. Nassif, M. Podda, E. P. Prens, F. Prignano, H. Raynal, M. Romanelli, D. M. L. Saunte, A. Szegedi, J. C. Szepietowski, T. Tzellos, S. Valiukevičienė, H. H. van der Zee, K. R. van Straalen, B. Villumsen, G. B. E. Jemec   +36 more
wiley   +1 more source

Standard Protocols for Characterising Primary and In Vitro‐Generated Human Hepatocytes

Journal of Cellular and Molecular Medicine, Volume 29, Issue 3, February 2025.
ABSTRACT Hepatocyte‐like cells (HLCs) derived from pluripotent stem cells (PSCs) or direct reprogramming are an unlimited source of human hepatocytes for biomedical applications. HLCs are used to model human diseases, develop precise drugs and establish groundbreaking regenerative cell‐based therapies.
Zahra Heydari, Roberto Gramignoli, Abbas Piryaei, Ensieh Zahmatkesh, Paria Pooyan, Homeyra Seydi, Andreas Nussler, Dagmara Szkolnicka, Hassan Rashidi, Mustapha Najimi, David C. Hay, Massoud Vosough   +11 more
wiley   +1 more source

Norgestrel causes oxidative damage to the digestive gland of the clam Mactra veneriformis

Aquaculture Reports
Increasingly, progestins are being detected in aquatic environments, especially in aquaculture areas, and concern about their adverse effects on aquatic organisms is growing.
Xiangfei Li, Yanyan Yang, Hua Xu, Jia Wang, Zhixu Chen, Baojun Liu, Linlin Fan, Yan Fang, Fan Li   +8 more
doaj   +1 more source

Hormonal Contraceptives: What if Exposed During Pregnancy?

Erciyes Medical Journal, 2019
Objective: Hormonal contraceptives are contraindicated in pregnancy. However, some women may become pregnant while using contraceptives to prevent pregnancy.
Duygun Altıntaş Aykan, Yusuf Ergün
doaj   +1 more source

Male contraceptive acceptability versus male acceptance of contraceptive responsibility

Andrology, Volume 12, Issue 7, Page 1585-1589, October 2024.
Abstract Despite the projected impact of new male contraceptives, resources and investments directed at their development remain limited in part due to concerns that men would not actually use them. Now, more than 30 studies have been conducted over the last 30 years—regionally and internationally, within clinical trials, and across populations ...
Brian T. Nguyen
wiley   +1 more source

Kristallographische Studie zum Sexualhormon-bindenden Globulin (SHBG) [PDF]

, 2002
Table of contents   Titelblatt List of abbreviations  2 Table of contents 4 1. Scientific background 6 1.1. Introduction 6 1.2. Sex hormone-binding globulin 7 1.3. The aim of my thesis  13 1.4.
Grishkovskaya, Irina
core   +1 more source

Pregnancy outcomes after first‐trimester exposure to fluoroquinolones: Findings based on an integrated database from two Japanese institutions

Congenital Anomalies, Volume 64, Issue 5, Page 199-206, September 2024.
Abstract Given the paucity of safety data on fluoroquinolone antibiotics in pregnancy, a prospective observational cohort study was conducted in pregnant women who sought help and advice on drug use at two teratology information institutes in Japan. The primary endpoint of the study was the incidence of major congenital anomalies.
Mikako Goto, Tatsuhiko Anzai, Ritsuko Yamane, Naho Yakuwa, Kunihiko Takahashi, Atsuko Murashima   +5 more
wiley   +1 more source

Modification of blood pressure in postmenopausal women: role of hormone replacement therapy [PDF]

, 2014
The rate of hypertension increases after menopause. Whether estrogen and progesterone deficiency associated with menopause play a role in determining a worst blood pressure (BP) control is still controversial.
Cagnacci, Angelo, Cannoletta, Marianna
core   +2 more sources

Distrofia simpática refleja (síndrome doloroso regional complejo tipo-I) asociada a Norplant®(L-Norgestrel): presentación del primer caso y revisión de la literatura

Revista Colombiana de Obstetricia y Ginecología, 2001
El dispositivo subdérmico NORPLANT® (L-Norgestrel) ha sido extensamente utilizado como anticonceptivo en todo el mundo desde hace más de quince años, demostrando ser un método reversible, seguro, efectivo y de alta aceptación por las usuarias.
Alonso A. Ruiz Perea, Iván Jaramillo Arias   +1 more
doaj