Results 121 to 130 of about 529,333 (248)

Retroactive Validation of Marriage according to 1983 Code of Canon Law (can. 1161-1165)

Kościół i Prawo, 2014
In the presented study, the author concentrated his attention on the functioning of the institution of a retroactive validation under the Code of 1983.
Paweł Stasiuk
doaj  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The International Learning Object Metadata Survey

International Review of Research in Open and Distributed Learning, 2004
Norm Friesen
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

A review of N. Peter Steeves' "Things Themselves: Phenomenology and the Return to the Everyday"

Phenomenology & Practice, 2007
Norm Friesen
doaj   +1 more source

Act Environmentally When Peers Do So? The Effect of Friends' and Strangers' Resource Extraction on Preschool Children's Pro-Environmental Behavior. [PDF]

Dev Sci
Li M, Liu C, Yang X, Xiu M, Wei Y, Xia J, Yu W, Yu F, Li H.   +8 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Skip the clockwork train and the jelly beans just make it a "coupla" dozen Ampol Exploration shares at par!! [picture] /

, 1953
Part of the collection: Ampol and Caltex photograph collection.; Title devised by cataloguer based on information supplied by donor.; Inscriptions: "December 1952. We strike oil in Western Australia. This cartoon by Norm.
Mitchell, Norm, 1920-
core  

The Impact of Chatbot Type and Normative Messaging on Chatbot Usage Intention Based on the Health Technology Acceptance Model: Randomized Controlled Trial. [PDF]

J Med Internet Res
Liao Y, Madeo A, Allen CG, Frey MK, Maxwell W, Schlechter C, Sharaf RN, Kawamoto K, Del Fiol G, Kaphingst KA.   +9 more
europepmc   +1 more source