Results 121 to 130 of about 419,995 (312)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Norm McKibben Interview

open access: yes, 2014
This interview is an oral history conducted by Linfield College archivist Rachael Cristine Woody and Whitman College archivist Melissa Salrin with Norm McKibben of Pepper Bridge Winery.
McKibben, Norm
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Robust and minimum norm pole assignment with periodic state feedback

open access: yes, 1998
A computational approach is proposed to solve the minimum norm and/or robust pole assignment problem for linear periodic discrete-time systems. The proposed approach uses a periodic Sylvester equation based parametrization of the periodic pole ...
Varga, A.
core  

Uniform bounds on the 1-norm of the inverse of lower triangular Toeplitz matrices

open access: yes, 2011
A uniform bound on the 1-norm is given for the inverse of a lower triangular Toeplitz matrix with non-negative monotonically decreasing entries whose limit is zero. The new bound is sharp under certain specified constraints.
J.Y. Yuan   +7 more
core   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Skip the clockwork train and the jelly beans just make it a "coupla" dozen Ampol Exploration shares at par!! [picture] /

open access: yes, 1953
Part of the collection: Ampol and Caltex photograph collection.; Title devised by cataloguer based on information supplied by donor.; Inscriptions: "December 1952. We strike oil in Western Australia. This cartoon by Norm.
Mitchell, Norm, 1920-
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Computation of H-infinity norm of linear discrete-time periodic systems

open access: yes, 2006
We propose an efficient an numerically reliable procedure for the computation of H-infinity norm of discrete-time linear periodic systems. The new procedure is general being applicable to both standard as well as descriptor periodic systems with time ...
Varga, Andreas
core  

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