A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
[Catalogue of the State Normal School at Salem]: Fifty-Fifth Year, 1908-1909
, 1909 The catalog contains information about the students, faculty, curriculum, admissions, rules and regulations, teaching methods, course descriptions,and resources at the Salem Normal ...
State Normal School at Salem
core +1 more source
[Catalogue of the State Normal School at Salem]: Sixty-Seventh Year, 1920-1921
, 1921 The catalog contains information about the students, faculty, curriculum, admissions, rules and regulations, teaching methods, course descriptions,and resources at the Salem Normal ...
State Normal School at Salem
core
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
[Catalogue of the State Normal School at Salem]: Fifty-Eighth Year, 1911-1912
, 1912 The catalog contains information about the students, faculty, curriculum, admissions, rules and regulations, teaching methods, course descriptions,and resources at the Salem Normal ...
State Normal School at Salem
core
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Are men aware of normal penile length and sexual function? A narrative review of the literature
Asian Journal of AndrologyMen frequently present to their health practitioners with concerns that they are not “normal” in the domains of sexual anatomy and function. This narrative review aims to synthesize the existing evidence on the general male population’s perception of ...
Yoonus Faizal +5 more
doaj +1 more source
Register and Circular of the State Normal School at Salem, Mass., 1883-1884.
, 1884 The catalog contains information about the students, faculty, curriculum, admissions, rules and regulations, teaching methods,and resources at the Salem Normal ...
State Normal School at Salem
core
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source